Promising druggable target in head and neck squamous cell carcinoma: Wnt signaling

Amnani Aminuddin, Pei Yuen Ng

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Canonical Wnt signaling pathway, also known as Wnt/β-catenin signaling pathway, is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Dysregulation of this pathway correlates with oncogenesis in various tissues including breast, colon, pancreatic as well as head and neck cancers. Furthermore, the canonical Wnt signaling pathway has also been described as one of the critical signaling pathways for regulation of normal stem cells as well as cancer cells with stem cell-like features, termed cancer stem cells (CSC). In this review, we will briefly describe the basic mechanisms of Wnt signaling pathway and its crucial roles in the normal regulation of cellular processes as well as in the development of cancer. Next, we will highlight the roles of canonical Wnt signaling pathway in the regulation of CSC properties namely self-renewal, differentiation, metastasis, and drug resistance abilities, particularly in head and neck squamous cell carcinoma. Finally, we will examine the findings of several recent studies which explore druggable targets in the canonical Wnt signaling pathway which could be valuable to improve the treatment outcome for head and neck cancer.

Original languageEnglish
Article number244
JournalFrontiers in Pharmacology
Volume7
Issue numberAUG
DOIs
Publication statusPublished - 12 Aug 2016

Fingerprint

Wnt Signaling Pathway
Neoplastic Stem Cells
Head and Neck Neoplasms
Stem Cells
Carcinoma, squamous cell of head and neck
Catenins
Critical Pathways
Drug Resistance
Neoplasms
Cell Cycle
Colon
Carcinogenesis
Breast
Maintenance
Apoptosis
Neoplasm Metastasis

Keywords

  • Cancer stem cells
  • Canonical Wnt signaling
  • Druggable target
  • Head and neck squamous cell carcinoma
  • β-catenin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Promising druggable target in head and neck squamous cell carcinoma : Wnt signaling. / Aminuddin, Amnani; Ng, Pei Yuen.

In: Frontiers in Pharmacology, Vol. 7, No. AUG, 244, 12.08.2016.

Research output: Contribution to journalReview article

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