Progressing the utilisation of pharmacogenetics and pharmacogenomics into clinical care

Ronald J. Trent, Pak Leng Cheong, Eng Wee Chua, Martin A. Kennedy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Understanding human genetic variation and how it impacts on gene function is a major focus in genomic-based research. Translation of this knowledge into clinical care is exemplified by pharmacogenetics/pharmacogenomics. The identification of particular gene variants that might influence drug uptake, metabolism, distribution or excretion promises a more effective personalised medicine approach in choosing the right drug or its dose for any particular individual. Adverse drug responses can then be avoided or mitigated. An understanding of germline or acquired (somatic) DNA mutations can also be used to identify drugs that are more likely to be therapeutically beneficial. This represents an area of growing interest in the treatment of cancer.

Original languageEnglish
Pages (from-to)357-370
Number of pages14
JournalPathology
Volume45
Issue number4
DOIs
Publication statusPublished - Jun 2013

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Pharmacogenetics
Pharmaceutical Preparations
Precision Medicine
Translational Medical Research
Medical Genetics
Genes
Mutation
DNA
Research
Neoplasms
Therapeutics

Keywords

  • Drug efficacy
  • Drug safety
  • Genetic testing
  • Molecular diagnostics
  • Personalised medicine
  • Pharmacogenetics
  • Pharmacogenomics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Progressing the utilisation of pharmacogenetics and pharmacogenomics into clinical care. / Trent, Ronald J.; Cheong, Pak Leng; Chua, Eng Wee; Kennedy, Martin A.

In: Pathology, Vol. 45, No. 4, 06.2013, p. 357-370.

Research output: Contribution to journalArticle

Trent, Ronald J. ; Cheong, Pak Leng ; Chua, Eng Wee ; Kennedy, Martin A. / Progressing the utilisation of pharmacogenetics and pharmacogenomics into clinical care. In: Pathology. 2013 ; Vol. 45, No. 4. pp. 357-370.
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