Profiling cell-free and circulating miRNA: a clinical diagnostic tool for different cancers

Chiranjib Chakraborty, Srijit Das

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Effective cancer management depends on early diagnosis and treatment. There are several microRNAs (miRNAs) which are used for detection of various cancers. Cell-free and circulating miRNAs originate from plasma, either from blood cells or endothelial cells. Cell-free and circulating miRNAs are very much important in the diagnosis and prognosis of cancer therapy. Admittedly, biological knowledge of extracellular miRNAs is still at its preliminary level. Recent discoveries of novel cell-free and circulating miRNAs from the body fluids are now being considered as important biomarkers that may help us in the early diagnosis of any cancer. In the present review, we highlight the biogenesis of miRNAs and their current extracellular pattern, the discovery of circulating miRNA, significant advantages, and different profiling techniques. Finally, we discuss the different circulating miRNAs such as miR-21, miR-20a, miR-155, miR‑221, miR-210, miR-218, miR-200-family, miR-141, miR-122, miR-486-5p, miR‑423-5p, miR-29a, and miR-500 for clinical diagnosis of various cancers. The present review may be beneficial for future researches concerned with miRNAs which are used for detection of various cancers.

Original languageEnglish
Pages (from-to)5705-5714
Number of pages10
JournalTumor Biology
Volume37
Issue number5
DOIs
Publication statusPublished - 1 May 2016

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MicroRNAs
Neoplasms
Body Fluids
Early Detection of Cancer
Early Diagnosis
Blood Cells
Endothelial Cells
Biomarkers
Research

Keywords

  • Biomarkers
  • Cancer
  • Diagnosis
  • miRNA

ASJC Scopus subject areas

  • Cancer Research

Cite this

Profiling cell-free and circulating miRNA : a clinical diagnostic tool for different cancers. / Chakraborty, Chiranjib; Das, Srijit.

In: Tumor Biology, Vol. 37, No. 5, 01.05.2016, p. 5705-5714.

Research output: Contribution to journalReview article

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