Profil Aktiviti Laktat Dehidrogenase, Asid Fosfatase Rintang Tartarat dan Alkalin Fosfatase pada Air Liur Semasa Rawatan Ortodontik

Translated title of the contribution: Profiles of lactate dehydrogenase, tartrate resistant acid phosphatase and alkaline phosphatase in saliva during orthodontic treatment

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

During orthodontic treatment, the progress of tooth movements can be classified into four stages, i.e. activation (related to tissue inflammation or cells'death), resorption, reversal and restructuring of new bones. Tooth movement is related to metabolic changes around the mouth. The objective of this study was to determine enzymes profiles from patient's saliva during orthodontic tooth movement, i.e., lactate dehydrogenase (LDH) for inflammation, tartrate resistant acid phosphatase (TRAP)for bone resorption and alkaline phosphatase (ALP)for bone formation. Saliva samples were collected from 6 orthodontic patients. Activities of all enzymes were measured before placement of orthodontic fixed appliances (normal activity) followed with day 3, 7, 10, 14, 17, 21, 24, 28 and 31 after the braces were activated. All enzymes (LDH, TRAP and ALP) showed significantly (p≤0.05) higher specific activities as compared to normal. LDH showed the increment at the early phase of treatment (day 3,7 and 10), TRAP at day 14 and 17 followed by ALP at day 17,21 and 24. As a conclusion, the profiles of enzymes activities showed that inflammation occured during early phase of treatment followed by bone resorption and bone formation. In addition, the inflammations, resorption and bone formation phases in orthodontic treatment were found to be completed within 24 days.

Original languageUndefined/Unknown
Pages (from-to)405-412
Number of pages8
JournalSains Malaysiana
Volume39
Issue number3
Publication statusPublished - Jun 2010

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Orthodontics
Tooth Movement Techniques
L-Lactate Dehydrogenase
Saliva
Alkaline Phosphatase
Osteogenesis
Inflammation
Enzymes
Bone Resorption
Orthodontic Appliances
Bone and Bones
Braces
Therapeutics
Mouth
Cell Death
Tartrate-Resistant Acid Phosphatase

Keywords

  • Air liur
  • Bone remodeling
  • Enzymes
  • Orthodontic

ASJC Scopus subject areas

  • General

Cite this

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title = "Profil Aktiviti Laktat Dehidrogenase, Asid Fosfatase Rintang Tartarat dan Alkalin Fosfatase pada Air Liur Semasa Rawatan Ortodontik",
abstract = "During orthodontic treatment, the progress of tooth movements can be classified into four stages, i.e. activation (related to tissue inflammation or cells'death), resorption, reversal and restructuring of new bones. Tooth movement is related to metabolic changes around the mouth. The objective of this study was to determine enzymes profiles from patient's saliva during orthodontic tooth movement, i.e., lactate dehydrogenase (LDH) for inflammation, tartrate resistant acid phosphatase (TRAP)for bone resorption and alkaline phosphatase (ALP)for bone formation. Saliva samples were collected from 6 orthodontic patients. Activities of all enzymes were measured before placement of orthodontic fixed appliances (normal activity) followed with day 3, 7, 10, 14, 17, 21, 24, 28 and 31 after the braces were activated. All enzymes (LDH, TRAP and ALP) showed significantly (p≤0.05) higher specific activities as compared to normal. LDH showed the increment at the early phase of treatment (day 3,7 and 10), TRAP at day 14 and 17 followed by ALP at day 17,21 and 24. As a conclusion, the profiles of enzymes activities showed that inflammation occured during early phase of treatment followed by bone resorption and bone formation. In addition, the inflammations, resorption and bone formation phases in orthodontic treatment were found to be completed within 24 days.",
keywords = "Air liur, Bone remodeling, Enzymes, Orthodontic",
author = "{Zainal Ariffin}, {Shahrul Hisham} and Ellias, {Mohd Faiz} and {Megat Abdul Wahab}, Rohaya and Yosni Bakar and Sahidan Senafi",
year = "2010",
month = "6",
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volume = "39",
pages = "405--412",
journal = "Sains Malaysiana",
issn = "0126-6039",
publisher = "Penerbit Universiti Kebangsaan Malaysia",
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T1 - Profil Aktiviti Laktat Dehidrogenase, Asid Fosfatase Rintang Tartarat dan Alkalin Fosfatase pada Air Liur Semasa Rawatan Ortodontik

AU - Zainal Ariffin, Shahrul Hisham

AU - Ellias, Mohd Faiz

AU - Megat Abdul Wahab, Rohaya

AU - Bakar, Yosni

AU - Senafi, Sahidan

PY - 2010/6

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N2 - During orthodontic treatment, the progress of tooth movements can be classified into four stages, i.e. activation (related to tissue inflammation or cells'death), resorption, reversal and restructuring of new bones. Tooth movement is related to metabolic changes around the mouth. The objective of this study was to determine enzymes profiles from patient's saliva during orthodontic tooth movement, i.e., lactate dehydrogenase (LDH) for inflammation, tartrate resistant acid phosphatase (TRAP)for bone resorption and alkaline phosphatase (ALP)for bone formation. Saliva samples were collected from 6 orthodontic patients. Activities of all enzymes were measured before placement of orthodontic fixed appliances (normal activity) followed with day 3, 7, 10, 14, 17, 21, 24, 28 and 31 after the braces were activated. All enzymes (LDH, TRAP and ALP) showed significantly (p≤0.05) higher specific activities as compared to normal. LDH showed the increment at the early phase of treatment (day 3,7 and 10), TRAP at day 14 and 17 followed by ALP at day 17,21 and 24. As a conclusion, the profiles of enzymes activities showed that inflammation occured during early phase of treatment followed by bone resorption and bone formation. In addition, the inflammations, resorption and bone formation phases in orthodontic treatment were found to be completed within 24 days.

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