Process optimization to improve the processing of poly (DL-lactide-co- glycolide) into 3D tissue engineering scaffolds

M. E. Hoque, Y. L. Chuan, I. Pashby, Min Hwei Ng, Ruszymah Idrus

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Rapid Prototyping (RP) technology is being widely used in diverse areas including tissue engineering scaffold (TES) manufacturing. However, the quality of manufacturing is significantly affected by the property of utilized materials and process parameters of the RP system. This study investigates and optimizes the process parameters for desktop robot-based rapid prototyping (DRBRP) technique to process biopolymer into 3D scaffolds. TES can be freeform fabricated according to various design configurations at room temperature with defined lay-down angle, filament diameter and filament distant. To find the most accurate dimension of the scaffold, controlling of extrusion pressure, material liquefier temperature and deposition speed were conducted. Light optical microscopy was employed to investigate and optimize the suitable process parameters. The process parameters were found to influence the scaffold morphology. However, the pore diameters of the built scaffold were in the viable range for tissue engineering applications. The optimal set of process parameters have been concluded from this study.

Original languageEnglish
Title of host publicationIFMBE Proceedings
Pages836-840
Number of pages5
Volume35 IFMBE
DOIs
Publication statusPublished - 2011
Event5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011 - Kuala Lumpur
Duration: 20 Jun 201123 Jun 2011

Other

Other5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011
CityKuala Lumpur
Period20/6/1123/6/11

Fingerprint

Tissue Scaffolds
Rapid prototyping
Scaffolds (biology)
Tissue engineering
Scaffolds
Optical microscopy
Processing
Biopolymers
Extrusion
Robots
Temperature
poly(lactide)

Keywords

  • extrusion
  • process parameter
  • rapid prototyping
  • scaffold
  • Tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Process optimization to improve the processing of poly (DL-lactide-co- glycolide) into 3D tissue engineering scaffolds. / Hoque, M. E.; Chuan, Y. L.; Pashby, I.; Ng, Min Hwei; Idrus, Ruszymah.

IFMBE Proceedings. Vol. 35 IFMBE 2011. p. 836-840.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hoque, ME, Chuan, YL, Pashby, I, Ng, MH & Idrus, R 2011, Process optimization to improve the processing of poly (DL-lactide-co- glycolide) into 3D tissue engineering scaffolds. in IFMBE Proceedings. vol. 35 IFMBE, pp. 836-840, 5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011, Kuala Lumpur, 20/6/11. https://doi.org/10.1007/978-3-642-21729-6_204
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