Probing the colorectal cancer proteome for biomarkers

Current status and perspectives

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. Biomarkers that can facilitate better clinical management of CRC are in high demand to improve patient outcome and to reduce mortality. In this regard, proteomic analysis holds a promising prospect in the hunt of novel biomarkers for CRC and in understanding the mechanisms underlying tumorigenesis. This review aims to provide an overview of the current progress of proteomic research, focusing on discovery and validation of diagnostic biomarkers for CRC. We will summarize the contributions of proteomic strategies to recent discoveries of protein biomarkers for CRC and also briefly discuss the potential and challenges of different proteomic approaches in biomarker discovery and translational applications.

Original languageEnglish
JournalJournal of Proteomics
DOIs
Publication statusAccepted/In press - 1 Jan 2018

Fingerprint

Biomarkers
Proteome
Tumor Biomarkers
Colorectal Neoplasms
Proteomics
Carcinogenesis
Mortality
Research
Neoplasms
Proteins

Keywords

  • Biomarker
  • Colorectal Cancer
  • Proteomics
  • Technologies

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

Cite this

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title = "Probing the colorectal cancer proteome for biomarkers: Current status and perspectives",
abstract = "Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. Biomarkers that can facilitate better clinical management of CRC are in high demand to improve patient outcome and to reduce mortality. In this regard, proteomic analysis holds a promising prospect in the hunt of novel biomarkers for CRC and in understanding the mechanisms underlying tumorigenesis. This review aims to provide an overview of the current progress of proteomic research, focusing on discovery and validation of diagnostic biomarkers for CRC. We will summarize the contributions of proteomic strategies to recent discoveries of protein biomarkers for CRC and also briefly discuss the potential and challenges of different proteomic approaches in biomarker discovery and translational applications.",
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AU - Chin, Siok Fong

AU - Teck Yew, Low

AU - A. Jamal, A. Rahman

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AB - Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. Biomarkers that can facilitate better clinical management of CRC are in high demand to improve patient outcome and to reduce mortality. In this regard, proteomic analysis holds a promising prospect in the hunt of novel biomarkers for CRC and in understanding the mechanisms underlying tumorigenesis. This review aims to provide an overview of the current progress of proteomic research, focusing on discovery and validation of diagnostic biomarkers for CRC. We will summarize the contributions of proteomic strategies to recent discoveries of protein biomarkers for CRC and also briefly discuss the potential and challenges of different proteomic approaches in biomarker discovery and translational applications.

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KW - Proteomics

KW - Technologies

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