Primary oesophageal Ki (CD30)-positive ALK+ anaplastic large cell lymphoma of T-cell phenotype

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6 Citations (Scopus)

Abstract

Primary oesophageal lymphoma is a very rare entity, with fewer than 30 reported cases worldwide. It represents an important cause of dysphagia. Most of the oesophageal lymphomas are diffuse large B-cell type, with only one reported case of anaplastic large cell lymphoma (ALCL) of T-cell phenotype. Primary oesophageal lymphomas that are not associated with an immunocompromised state tend to affect elderly patients. We describe the first case of primary oesophageal Ki (CD30)-positive ALK+ALCL of T-cell phenotype in a 34-year-old immunocompetent woman, who presented with a two-year history of dysphagia. She was treated with chemotherapy and endoscopic oesophageal dilations and stenting, resulting in complete remission of the lymphoma and resolution of the dysphagia. She then underwent autologous peripheral blood haematopoietic stem cell transplantation and remained disease-free two years after the diagnosis.

Original languageEnglish
JournalSingapore Medical Journal
Volume49
Issue number10
Publication statusPublished - Oct 2008

Fingerprint

Anaplastic Large-Cell Lymphoma
Deglutition Disorders
Lymphoma
T-Lymphocytes
Phenotype
Peripheral Blood Stem Cell Transplantation
Lymphoma, Large B-Cell, Diffuse
Hematopoietic Stem Cell Transplantation
Dilatation
Drug Therapy

Keywords

  • Anaplastic large cell lymphoma
  • Anaplastic lymphoma kinase
  • Dysphagia
  • Ki (CD30)-positive ALK
  • Lymphoma
  • Primary oesophageal lymphoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Primary oesophageal Ki (CD30)-positive ALK+ anaplastic large cell lymphoma of T-cell phenotype",
abstract = "Primary oesophageal lymphoma is a very rare entity, with fewer than 30 reported cases worldwide. It represents an important cause of dysphagia. Most of the oesophageal lymphomas are diffuse large B-cell type, with only one reported case of anaplastic large cell lymphoma (ALCL) of T-cell phenotype. Primary oesophageal lymphomas that are not associated with an immunocompromised state tend to affect elderly patients. We describe the first case of primary oesophageal Ki (CD30)-positive ALK+ALCL of T-cell phenotype in a 34-year-old immunocompetent woman, who presented with a two-year history of dysphagia. She was treated with chemotherapy and endoscopic oesophageal dilations and stenting, resulting in complete remission of the lymphoma and resolution of the dysphagia. She then underwent autologous peripheral blood haematopoietic stem cell transplantation and remained disease-free two years after the diagnosis.",
keywords = "Anaplastic large cell lymphoma, Anaplastic lymphoma kinase, Dysphagia, Ki (CD30)-positive ALK, Lymphoma, Primary oesophageal lymphoma",
author = "Hayati Yaakup and Ismail Sagap and {S. Abdul Wahid}, {S Fadilah}",
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TY - JOUR

T1 - Primary oesophageal Ki (CD30)-positive ALK+ anaplastic large cell lymphoma of T-cell phenotype

AU - Yaakup, Hayati

AU - Sagap, Ismail

AU - S. Abdul Wahid, S Fadilah

PY - 2008/10

Y1 - 2008/10

N2 - Primary oesophageal lymphoma is a very rare entity, with fewer than 30 reported cases worldwide. It represents an important cause of dysphagia. Most of the oesophageal lymphomas are diffuse large B-cell type, with only one reported case of anaplastic large cell lymphoma (ALCL) of T-cell phenotype. Primary oesophageal lymphomas that are not associated with an immunocompromised state tend to affect elderly patients. We describe the first case of primary oesophageal Ki (CD30)-positive ALK+ALCL of T-cell phenotype in a 34-year-old immunocompetent woman, who presented with a two-year history of dysphagia. She was treated with chemotherapy and endoscopic oesophageal dilations and stenting, resulting in complete remission of the lymphoma and resolution of the dysphagia. She then underwent autologous peripheral blood haematopoietic stem cell transplantation and remained disease-free two years after the diagnosis.

AB - Primary oesophageal lymphoma is a very rare entity, with fewer than 30 reported cases worldwide. It represents an important cause of dysphagia. Most of the oesophageal lymphomas are diffuse large B-cell type, with only one reported case of anaplastic large cell lymphoma (ALCL) of T-cell phenotype. Primary oesophageal lymphomas that are not associated with an immunocompromised state tend to affect elderly patients. We describe the first case of primary oesophageal Ki (CD30)-positive ALK+ALCL of T-cell phenotype in a 34-year-old immunocompetent woman, who presented with a two-year history of dysphagia. She was treated with chemotherapy and endoscopic oesophageal dilations and stenting, resulting in complete remission of the lymphoma and resolution of the dysphagia. She then underwent autologous peripheral blood haematopoietic stem cell transplantation and remained disease-free two years after the diagnosis.

KW - Anaplastic large cell lymphoma

KW - Anaplastic lymphoma kinase

KW - Dysphagia

KW - Ki (CD30)-positive ALK

KW - Lymphoma

KW - Primary oesophageal lymphoma

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