Preventing the withdrawal response associated with rocuronium injection

A comparison of fentanyl with lidocaine

Norezalee Ahmad, Choy Yin Choy, Esa Ab Aris, Subrahmanyam Balan

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

We compared the efficacy of IV fentanyl with IV lidocaine as pretreatment for the prevention of withdrawal response after rocuronium injection. For this prospective, randomized, placebo-controlled, double-blind study we recruited 90 patients aged between 18 and 65 yr, ASA physical status I or II, who had undergone elective surgery requiring general anesthesia and positive pressure ventilation. Patients were randomly allocated to 1 of 3 groups: group F received 2 mL IV fentanyl 50 μg/mL (100 μg), group L received 2 mL of preservative-free lidocaine 2% (40 mg), and group P (placebo) received 2 mL of normal saline. The incidence of withdrawal response after rocuronium was 57%, 30%, and 7% in the placebo, lidocaine, and fentanyl groups, respectively. We found a significant reduction in incidence of withdrawal response in both the fentanyl and lidocaine groups when compared with the placebo group (P < 0.05), with the fentanyl group being most effective (P < 0.05). In conclusion, both fentanyl and lidocaine are effective clinical treatments to alleviate the withdrawal response associated with rocuronium injection, with fentanyl being more effective.

Original languageEnglish
Pages (from-to)987-990
Number of pages4
JournalAnesthesia and Analgesia
Volume100
Issue number4
DOIs
Publication statusPublished - Apr 2005
Externally publishedYes

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Fentanyl
Lidocaine
Injections
Placebos
Positive-Pressure Respiration
Incidence
rocuronium
Double-Blind Method
General Anesthesia

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Preventing the withdrawal response associated with rocuronium injection : A comparison of fentanyl with lidocaine. / Ahmad, Norezalee; Choy, Choy Yin; Aris, Esa Ab; Balan, Subrahmanyam.

In: Anesthesia and Analgesia, Vol. 100, No. 4, 04.2005, p. 987-990.

Research output: Contribution to journalArticle

Ahmad, Norezalee ; Choy, Choy Yin ; Aris, Esa Ab ; Balan, Subrahmanyam. / Preventing the withdrawal response associated with rocuronium injection : A comparison of fentanyl with lidocaine. In: Anesthesia and Analgesia. 2005 ; Vol. 100, No. 4. pp. 987-990.
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