Prevalence of Proteus species with reduced susceptibility to imipenem isolated from a tertiary referral hospital in Malaysia

Rinni Damayanti Samsuddin, Anita Sulong, Nurzam Suhaila Che Hussin, Zalina Ismail

Research output: Contribution to journalArticle

Abstract

Aims: Proteus species are implicated as serious causes of various human infections. Imipenem has been used to treat infections caused by these organisms. However, Proteus spp. are known to have reduced susceptibility and have elevated minimum inhibitory concentration (MIC) towards imipenem. The aim of this study was to determine the prevalence of Proteus species with reduced susceptibility to imipenem and the antibiotic susceptibility pattern for each Proteus species. Methodology and results: A total of 204 Proteus isolates were collected from routine samples. All isolates were identified by using VITEK® 2 GN ID card. Antibiotic susceptibility tests were done by using disc diffusion method and imipenem E-test. While 5.9% of the Proteus isolates showed reduced susceptibility towards imipenem by disc diffusion, only 1% (2 out of 204 isolates) has reduced susceptibility by E-test. Conclusion, significance and impact of study: The prevalence of Proteus species with reduced susceptibility to imipenem is still low. The imipenem zone diameter does not truly reflect the MIC value and thus, in any isolates which are tested to have reduced susceptibility or resistant to imipenem should always be followed by imipenem MIC method.

Original languageEnglish
Pages (from-to)513-518
Number of pages6
JournalMalaysian Journal of Microbiology
Volume14
Issue numberSpecialissue6
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Proteus
Imipenem
Malaysia
Tertiary Care Centers
Microbial Sensitivity Tests
Anti-Bacterial Agents
Infection
Cross-Sectional Studies

Keywords

  • Imipenem
  • Proteus
  • Reduced susceptibility
  • Resistant

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Prevalence of Proteus species with reduced susceptibility to imipenem isolated from a tertiary referral hospital in Malaysia. / Samsuddin, Rinni Damayanti; Sulong, Anita; Che Hussin, Nurzam Suhaila; Ismail, Zalina.

In: Malaysian Journal of Microbiology, Vol. 14, No. Specialissue6, 01.01.2018, p. 513-518.

Research output: Contribution to journalArticle

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