Prevalence and risk factors of premature coronary artery disease: A comparative cross-sectional study between two time frames in Malaysia

Shamsul Azhar Shah, Lee Jing, Muhammad Syahmi Khalid, Fatimah Najid, Intan Sabrina Haniff, Azmee Mohd Ghazi, Ika Faizura Mohd Nor, Rosli Mohd Ali, Wan Zurinah Wan Ngah

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Limited studies on prevalence and risk factors of Premature Coronary Artery Disease (PCAD) were done in Malaysia, primarily on lipid profile. This cross sectional study aims to identify any changing patterns in prevalence and risk factors of Premature CAD between 2000 and 2012. From 2000 to 2012 we included 21862 patients who underwent the first Percutaneous Coronary Intervention (PCI). Analysis of risk factors was done to 1660 and 2098 patients from year 2007 and 2012 respectively. Age of less than 45 years was taken as PCAD. Data was collected from PCI database of National Heart Institute (NHI), NHI TrakCare System, and patients' medical records. PCAD significantly decreased from 18.8% (2000) to 11.6% (2012). Malay ethnicity showed increasing trend over the years from 55.1% to 66.9%. Multiple logistic regression analysis in 2007 showed that smoking had the higher risk (AOR=2.52), followed by male gender (AOR=2.06), family history of PCAD (AOR=1.96), Indian ethnicity, (AOR=1.65), triglycerides level (AOR=1.20) and BMI (AOR=1.06). In 2012, family history of PCAD had the highest risk (AOR=2.00) followed by smoking (AOR=1.91) and BMI (AOR=1.11). There are changes in risk factors patterns of premature CAD between 2007 and 2012. Most of them are preventable at earlier stage.

Original languageEnglish
Pages (from-to)157-166
Number of pages10
JournalMalaysian Journal of Public Health Medicine
Volume15
Issue number3
Publication statusPublished - 2015

Fingerprint

Malaysia
Coronary Artery Disease
Cross-Sectional Studies
Percutaneous Coronary Intervention
Smoking
Medical Records
Triglycerides
Logistic Models
Regression Analysis
Databases
Lipids

Keywords

  • Premature coronary artery disease
  • Prevalence
  • Risk factors

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Prevalence and risk factors of premature coronary artery disease : A comparative cross-sectional study between two time frames in Malaysia. / Shah, Shamsul Azhar; Jing, Lee; Khalid, Muhammad Syahmi; Najid, Fatimah; Haniff, Intan Sabrina; Ghazi, Azmee Mohd; Nor, Ika Faizura Mohd; Ali, Rosli Mohd; Wan Ngah, Wan Zurinah.

In: Malaysian Journal of Public Health Medicine, Vol. 15, No. 3, 2015, p. 157-166.

Research output: Contribution to journalArticle

Shah, SA, Jing, L, Khalid, MS, Najid, F, Haniff, IS, Ghazi, AM, Nor, IFM, Ali, RM & Wan Ngah, WZ 2015, 'Prevalence and risk factors of premature coronary artery disease: A comparative cross-sectional study between two time frames in Malaysia', Malaysian Journal of Public Health Medicine, vol. 15, no. 3, pp. 157-166.
Shah, Shamsul Azhar ; Jing, Lee ; Khalid, Muhammad Syahmi ; Najid, Fatimah ; Haniff, Intan Sabrina ; Ghazi, Azmee Mohd ; Nor, Ika Faizura Mohd ; Ali, Rosli Mohd ; Wan Ngah, Wan Zurinah. / Prevalence and risk factors of premature coronary artery disease : A comparative cross-sectional study between two time frames in Malaysia. In: Malaysian Journal of Public Health Medicine. 2015 ; Vol. 15, No. 3. pp. 157-166.
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