Presence of anti-mitochondrial antibodies and elevated serum immunoglobulin G levels

Is this primary biliary cirrhosis-autoimmune hepatitis overlap syndrome?

Research output: Contribution to journalArticle

Abstract

Primary biliary cirrhosis in combination with autoimmune hepatitis has been termed “overlap syndrome”, but its diagnosis is challenging. We report a case of a 43-year-old lady who presented with a six-month history of jaundice and pruritus. She subsequently developed gum bleeds. Laboratory investigations revealed hypochromic microcytic anemia, abnormal coagulation profiles, elevated serum alanine transferase and alkaline phosphatase levels, and raised serum IgG and IgM levels. Her serum was also positive for anti-nuclear and anti-mitochondrial antibodies. The findings from her abdominal CT scan were suggestive of early liver cirrhosis and the histopathological examination results of her liver biopsy were consistent with primary biliary cirrhosis. The patient was treated with ursodeoxycholic acid and her liver function test parameters normalized after six months.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalEXCLI Journal
Volume14
DOIs
Publication statusPublished - 30 Jan 2015

Fingerprint

autoimmune hepatitis
ursodeoxycholic acid
Autoimmune Hepatitis
jaundice
liver cirrhosis
pruritus
Biliary Liver Cirrhosis
liver function
immunoglobulin G
coagulation
computed tomography
transferases
anemia
alanine
alkaline phosphatase
biopsy
Anti-Idiotypic Antibodies
Immunoglobulin G
case studies
liver

Keywords

  • Anti-mitochondrial antibody
  • Anti-nuclear antibody
  • Autoimmune hepatitis
  • Overlap syndrome
  • Primary biliary cirrhosis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Animal Science and Zoology

Cite this

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title = "Presence of anti-mitochondrial antibodies and elevated serum immunoglobulin G levels: Is this primary biliary cirrhosis-autoimmune hepatitis overlap syndrome?",
abstract = "Primary biliary cirrhosis in combination with autoimmune hepatitis has been termed “overlap syndrome”, but its diagnosis is challenging. We report a case of a 43-year-old lady who presented with a six-month history of jaundice and pruritus. She subsequently developed gum bleeds. Laboratory investigations revealed hypochromic microcytic anemia, abnormal coagulation profiles, elevated serum alanine transferase and alkaline phosphatase levels, and raised serum IgG and IgM levels. Her serum was also positive for anti-nuclear and anti-mitochondrial antibodies. The findings from her abdominal CT scan were suggestive of early liver cirrhosis and the histopathological examination results of her liver biopsy were consistent with primary biliary cirrhosis. The patient was treated with ursodeoxycholic acid and her liver function test parameters normalized after six months.",
keywords = "Anti-mitochondrial antibody, Anti-nuclear antibody, Autoimmune hepatitis, Overlap syndrome, Primary biliary cirrhosis",
author = "{Abdul Samat}, {Muttaqillah Najihan} and {Abdul Wahab}, Asrul and Ding, {Chuan Hun} and Marlyn Mohammad and Suvra Biswas and Rahman, {Md. Mostafizur}",
year = "2015",
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TY - JOUR

T1 - Presence of anti-mitochondrial antibodies and elevated serum immunoglobulin G levels

T2 - Is this primary biliary cirrhosis-autoimmune hepatitis overlap syndrome?

AU - Abdul Samat, Muttaqillah Najihan

AU - Abdul Wahab, Asrul

AU - Ding, Chuan Hun

AU - Mohammad, Marlyn

AU - Biswas, Suvra

AU - Rahman, Md. Mostafizur

PY - 2015/1/30

Y1 - 2015/1/30

N2 - Primary biliary cirrhosis in combination with autoimmune hepatitis has been termed “overlap syndrome”, but its diagnosis is challenging. We report a case of a 43-year-old lady who presented with a six-month history of jaundice and pruritus. She subsequently developed gum bleeds. Laboratory investigations revealed hypochromic microcytic anemia, abnormal coagulation profiles, elevated serum alanine transferase and alkaline phosphatase levels, and raised serum IgG and IgM levels. Her serum was also positive for anti-nuclear and anti-mitochondrial antibodies. The findings from her abdominal CT scan were suggestive of early liver cirrhosis and the histopathological examination results of her liver biopsy were consistent with primary biliary cirrhosis. The patient was treated with ursodeoxycholic acid and her liver function test parameters normalized after six months.

AB - Primary biliary cirrhosis in combination with autoimmune hepatitis has been termed “overlap syndrome”, but its diagnosis is challenging. We report a case of a 43-year-old lady who presented with a six-month history of jaundice and pruritus. She subsequently developed gum bleeds. Laboratory investigations revealed hypochromic microcytic anemia, abnormal coagulation profiles, elevated serum alanine transferase and alkaline phosphatase levels, and raised serum IgG and IgM levels. Her serum was also positive for anti-nuclear and anti-mitochondrial antibodies. The findings from her abdominal CT scan were suggestive of early liver cirrhosis and the histopathological examination results of her liver biopsy were consistent with primary biliary cirrhosis. The patient was treated with ursodeoxycholic acid and her liver function test parameters normalized after six months.

KW - Anti-mitochondrial antibody

KW - Anti-nuclear antibody

KW - Autoimmune hepatitis

KW - Overlap syndrome

KW - Primary biliary cirrhosis

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