Predictors of thickened carotid intima media thickness among well controlled lupus nephritis patients in a Malaysian tertiary centre

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives. To investigate the prevalence of thickened carotid intima media thickness (CIMT) and its associated risk factors in patients with lupus nephritis (LN) who were in remission. Methods. This was a cross sectional study in which consecutive LN patients who were in remission and attending our Nephrology/SLE Clinic were included. Their demographic profile, traditional cardiovascular risk factors and treatment medications were evaluated by clinical interview and review of medical records. Carotid intima media thickness (CIMT) was measured using B Mode carotid ultrasonography. CIMT was considered to be abnormally thickened if it exceeded the 75th percentile matched for age-and sex-matched normal controls. The associated factors for thickened CIMT were examined. Results. A total of 39 patients with a mean remission duration of 29±24.3 months and on a mean prednisolone dose of 9.10±7.83 mg daily completed the study. Six patients (15.4%) had thickened CIMT. On univariate analysis, male gender, patient age, older age at diagnosis, higher serum CRP levels, greater proteinuria and higher mean cumulative azathioprine dose were associated with thickened CIMT (P<0.05). Lower mean cumulative doses of cyclosporine A (CyA) and mycophenolic acid (MPA) (P<0.05) each were associated with thickened CIMT. Using regression analysis, the associated factors of CIMT were older age at diagnosis and proteinuria. Conclusions. Lupus factors particularly age at diagnosis and proteinuria were the associated factors of thickened CIMT. Larger prospective trials are indicated to confirm our findings.

Original languageEnglish
Pages (from-to)341-349
Number of pages9
JournalReumatismo
Volume64
Issue number6
Publication statusPublished - 2012

Fingerprint

Carotid Intima-Media Thickness
Lupus Nephritis
Proteinuria
Mycophenolic Acid
Nephrology
Age Factors
Azathioprine
Prednisolone
Cyclosporine
Medical Records
Ultrasonography
Cross-Sectional Studies
Regression Analysis
Demography
Interviews

Keywords

  • Carotid intima media thickness (CIMT)
  • Lupus nephritis
  • Proteinuria
  • Remission

ASJC Scopus subject areas

  • Rheumatology

Cite this

@article{e4f455e518a7464a9ee248e1e7861de5,
title = "Predictors of thickened carotid intima media thickness among well controlled lupus nephritis patients in a Malaysian tertiary centre",
abstract = "Objectives. To investigate the prevalence of thickened carotid intima media thickness (CIMT) and its associated risk factors in patients with lupus nephritis (LN) who were in remission. Methods. This was a cross sectional study in which consecutive LN patients who were in remission and attending our Nephrology/SLE Clinic were included. Their demographic profile, traditional cardiovascular risk factors and treatment medications were evaluated by clinical interview and review of medical records. Carotid intima media thickness (CIMT) was measured using B Mode carotid ultrasonography. CIMT was considered to be abnormally thickened if it exceeded the 75th percentile matched for age-and sex-matched normal controls. The associated factors for thickened CIMT were examined. Results. A total of 39 patients with a mean remission duration of 29±24.3 months and on a mean prednisolone dose of 9.10±7.83 mg daily completed the study. Six patients (15.4{\%}) had thickened CIMT. On univariate analysis, male gender, patient age, older age at diagnosis, higher serum CRP levels, greater proteinuria and higher mean cumulative azathioprine dose were associated with thickened CIMT (P<0.05). Lower mean cumulative doses of cyclosporine A (CyA) and mycophenolic acid (MPA) (P<0.05) each were associated with thickened CIMT. Using regression analysis, the associated factors of CIMT were older age at diagnosis and proteinuria. Conclusions. Lupus factors particularly age at diagnosis and proteinuria were the associated factors of thickened CIMT. Larger prospective trials are indicated to confirm our findings.",
keywords = "Carotid intima media thickness (CIMT), Lupus nephritis, Proteinuria, Remission",
author = "Shaharir, {Syahrul Sazliyana} and {Mohamed Said}, {Mohd Shahrir} and Kong, {N. C T}",
year = "2012",
language = "English",
volume = "64",
pages = "341--349",
journal = "Reumatismo",
issn = "0048-7449",
publisher = "Societa Italiana di Reumatologia",
number = "6",

}

TY - JOUR

T1 - Predictors of thickened carotid intima media thickness among well controlled lupus nephritis patients in a Malaysian tertiary centre

AU - Shaharir, Syahrul Sazliyana

AU - Mohamed Said, Mohd Shahrir

AU - Kong, N. C T

PY - 2012

Y1 - 2012

N2 - Objectives. To investigate the prevalence of thickened carotid intima media thickness (CIMT) and its associated risk factors in patients with lupus nephritis (LN) who were in remission. Methods. This was a cross sectional study in which consecutive LN patients who were in remission and attending our Nephrology/SLE Clinic were included. Their demographic profile, traditional cardiovascular risk factors and treatment medications were evaluated by clinical interview and review of medical records. Carotid intima media thickness (CIMT) was measured using B Mode carotid ultrasonography. CIMT was considered to be abnormally thickened if it exceeded the 75th percentile matched for age-and sex-matched normal controls. The associated factors for thickened CIMT were examined. Results. A total of 39 patients with a mean remission duration of 29±24.3 months and on a mean prednisolone dose of 9.10±7.83 mg daily completed the study. Six patients (15.4%) had thickened CIMT. On univariate analysis, male gender, patient age, older age at diagnosis, higher serum CRP levels, greater proteinuria and higher mean cumulative azathioprine dose were associated with thickened CIMT (P<0.05). Lower mean cumulative doses of cyclosporine A (CyA) and mycophenolic acid (MPA) (P<0.05) each were associated with thickened CIMT. Using regression analysis, the associated factors of CIMT were older age at diagnosis and proteinuria. Conclusions. Lupus factors particularly age at diagnosis and proteinuria were the associated factors of thickened CIMT. Larger prospective trials are indicated to confirm our findings.

AB - Objectives. To investigate the prevalence of thickened carotid intima media thickness (CIMT) and its associated risk factors in patients with lupus nephritis (LN) who were in remission. Methods. This was a cross sectional study in which consecutive LN patients who were in remission and attending our Nephrology/SLE Clinic were included. Their demographic profile, traditional cardiovascular risk factors and treatment medications were evaluated by clinical interview and review of medical records. Carotid intima media thickness (CIMT) was measured using B Mode carotid ultrasonography. CIMT was considered to be abnormally thickened if it exceeded the 75th percentile matched for age-and sex-matched normal controls. The associated factors for thickened CIMT were examined. Results. A total of 39 patients with a mean remission duration of 29±24.3 months and on a mean prednisolone dose of 9.10±7.83 mg daily completed the study. Six patients (15.4%) had thickened CIMT. On univariate analysis, male gender, patient age, older age at diagnosis, higher serum CRP levels, greater proteinuria and higher mean cumulative azathioprine dose were associated with thickened CIMT (P<0.05). Lower mean cumulative doses of cyclosporine A (CyA) and mycophenolic acid (MPA) (P<0.05) each were associated with thickened CIMT. Using regression analysis, the associated factors of CIMT were older age at diagnosis and proteinuria. Conclusions. Lupus factors particularly age at diagnosis and proteinuria were the associated factors of thickened CIMT. Larger prospective trials are indicated to confirm our findings.

KW - Carotid intima media thickness (CIMT)

KW - Lupus nephritis

KW - Proteinuria

KW - Remission

UR - http://www.scopus.com/inward/record.url?scp=84872051835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872051835&partnerID=8YFLogxK

M3 - Article

C2 - 23285477

AN - SCOPUS:84872051835

VL - 64

SP - 341

EP - 349

JO - Reumatismo

JF - Reumatismo

SN - 0048-7449

IS - 6

ER -