Predictors of the yield of mobilized peripheral blood CD34+ cells in HLA-matched sibling donor

S Fadilah S. Abdul Wahid, M. I. Mohd-Razif, Z. A Z Seery, Nor Rafeah Tumian, W. J. Wan-Fariza, A. Habsah, Leong Chooi Fun

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We examined the donor factors that may affect the yield of peripheral blood stem cell (PBSC) mobilized from healthy donors. Pre-apheresis PB-CD34+ cell count was the only factor that correlated with PBSC yield. Leukocyte count (LC) and monocyte count (MC) correlated with PB-CD34+ cell. Male gender and PB-CD34+ cell count of at least 87.1/μL and 69.8/μL on day-4 and -5 of G-CSF were associated with the ability to harvest at least 5×106/kg CD34+ cells after one apheresis. We concluded that gender and PB-CD34+ cell count are important predictors of PBSC yield. LC and MC may serve as surrogate markers for estimating the PB-CD34+ cell count.

Original languageEnglish
Pages (from-to)583-589
Number of pages7
JournalTransfusion and Apheresis Science
Volume49
Issue number3
DOIs
Publication statusPublished - Dec 2013

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Blood Cells
Cell Count
Blood Component Removal
Leukocyte Count
Monocytes
Granulocyte Colony-Stimulating Factor
Biomarkers
Peripheral Blood Stem Cells

Keywords

  • Healthy donors
  • Peripheral blood CD34 cell count
  • Peripheral blood stem cell (PBSC) mobilization

ASJC Scopus subject areas

  • Hematology

Cite this

Predictors of the yield of mobilized peripheral blood CD34+ cells in HLA-matched sibling donor. / S. Abdul Wahid, S Fadilah; Mohd-Razif, M. I.; Seery, Z. A Z; Tumian, Nor Rafeah; Wan-Fariza, W. J.; Habsah, A.; Chooi Fun, Leong.

In: Transfusion and Apheresis Science, Vol. 49, No. 3, 12.2013, p. 583-589.

Research output: Contribution to journalArticle

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