Predictors of failed closure of patent ductus arteriosus with indomethacin

Nem Yun Boo, I. Mohd-Amin, Bilkis Banu Shri Abd. Aziz, F. Yong-Junina

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Introduction: The aim of this study was to determine predictors of failed closure of patent ductus arteriosus (PDA) following a single course of indomethacin in symptomatic preterm infants. Methods: This prospective observational study was carried out on 60 preterm infants weighing less than 1,750 g with symptomatic PDA confirmed by echocardiography. At a median age of 7.0 days (interquartile range 4.0), they were given indomethacin of 0.1 mg/kg/day intravenously daily for six days. Closure of PDA was reassessed by echocardiography upon completion of therapy. Results: The PDA of 40 percent (n=24) of these infants remained patent. Forward logistic regression analysis showed that the only significant predictors of failed PDA closure in these infants were: PDA size (adjusted odds-ratio [OR] is 7.0; 95 percent confidence interval [CI] of OR is 2.0, 24.8; p-value is 0.002), birth weight (adjusted OR is 0.996; 95 percent CI of OR is 0.993, 1.000; p-value is 0.03) and platelet count (adjusted OR is 0.987; 95 percent CI is 0.975, 1.000; p-value is 0.045). Gestational age, maternal age and left atrium/aorta ratios were not significant predictors. Conclusion: Larger PDA, lower birth weight and lower platelet count were significant predictors of high failure in indomethacin therapy given late at one week of life.

Original languageEnglish
Pages (from-to)763-768
Number of pages6
JournalSingapore Medical Journal
Volume47
Issue number9
Publication statusPublished - Sep 2006

Fingerprint

Patent Ductus Arteriosus
Indomethacin
Odds Ratio
Confidence Intervals
Platelet Count
Birth Weight
Premature Infants
Echocardiography
Surrogate Mothers
Maternal Age
Heart Atria
Gestational Age
Observational Studies
Aorta
Logistic Models
Regression Analysis
Prospective Studies
Therapeutics

Keywords

  • Indomethacin therapy
  • Patent ductus arteriosus
  • Preterm infants

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Predictors of failed closure of patent ductus arteriosus with indomethacin. / Boo, Nem Yun; Mohd-Amin, I.; Shri Abd. Aziz, Bilkis Banu; Yong-Junina, F.

In: Singapore Medical Journal, Vol. 47, No. 9, 09.2006, p. 763-768.

Research output: Contribution to journalArticle

Boo, Nem Yun ; Mohd-Amin, I. ; Shri Abd. Aziz, Bilkis Banu ; Yong-Junina, F. / Predictors of failed closure of patent ductus arteriosus with indomethacin. In: Singapore Medical Journal. 2006 ; Vol. 47, No. 9. pp. 763-768.
@article{f76f4d3f919144e89f43d5faf2e99739,
title = "Predictors of failed closure of patent ductus arteriosus with indomethacin",
abstract = "Introduction: The aim of this study was to determine predictors of failed closure of patent ductus arteriosus (PDA) following a single course of indomethacin in symptomatic preterm infants. Methods: This prospective observational study was carried out on 60 preterm infants weighing less than 1,750 g with symptomatic PDA confirmed by echocardiography. At a median age of 7.0 days (interquartile range 4.0), they were given indomethacin of 0.1 mg/kg/day intravenously daily for six days. Closure of PDA was reassessed by echocardiography upon completion of therapy. Results: The PDA of 40 percent (n=24) of these infants remained patent. Forward logistic regression analysis showed that the only significant predictors of failed PDA closure in these infants were: PDA size (adjusted odds-ratio [OR] is 7.0; 95 percent confidence interval [CI] of OR is 2.0, 24.8; p-value is 0.002), birth weight (adjusted OR is 0.996; 95 percent CI of OR is 0.993, 1.000; p-value is 0.03) and platelet count (adjusted OR is 0.987; 95 percent CI is 0.975, 1.000; p-value is 0.045). Gestational age, maternal age and left atrium/aorta ratios were not significant predictors. Conclusion: Larger PDA, lower birth weight and lower platelet count were significant predictors of high failure in indomethacin therapy given late at one week of life.",
keywords = "Indomethacin therapy, Patent ductus arteriosus, Preterm infants",
author = "Boo, {Nem Yun} and I. Mohd-Amin and {Shri Abd. Aziz}, {Bilkis Banu} and F. Yong-Junina",
year = "2006",
month = "9",
language = "English",
volume = "47",
pages = "763--768",
journal = "Singapore Medical Journal",
issn = "0037-5675",
publisher = "Singapore Medical Association",
number = "9",

}

TY - JOUR

T1 - Predictors of failed closure of patent ductus arteriosus with indomethacin

AU - Boo, Nem Yun

AU - Mohd-Amin, I.

AU - Shri Abd. Aziz, Bilkis Banu

AU - Yong-Junina, F.

PY - 2006/9

Y1 - 2006/9

N2 - Introduction: The aim of this study was to determine predictors of failed closure of patent ductus arteriosus (PDA) following a single course of indomethacin in symptomatic preterm infants. Methods: This prospective observational study was carried out on 60 preterm infants weighing less than 1,750 g with symptomatic PDA confirmed by echocardiography. At a median age of 7.0 days (interquartile range 4.0), they were given indomethacin of 0.1 mg/kg/day intravenously daily for six days. Closure of PDA was reassessed by echocardiography upon completion of therapy. Results: The PDA of 40 percent (n=24) of these infants remained patent. Forward logistic regression analysis showed that the only significant predictors of failed PDA closure in these infants were: PDA size (adjusted odds-ratio [OR] is 7.0; 95 percent confidence interval [CI] of OR is 2.0, 24.8; p-value is 0.002), birth weight (adjusted OR is 0.996; 95 percent CI of OR is 0.993, 1.000; p-value is 0.03) and platelet count (adjusted OR is 0.987; 95 percent CI is 0.975, 1.000; p-value is 0.045). Gestational age, maternal age and left atrium/aorta ratios were not significant predictors. Conclusion: Larger PDA, lower birth weight and lower platelet count were significant predictors of high failure in indomethacin therapy given late at one week of life.

AB - Introduction: The aim of this study was to determine predictors of failed closure of patent ductus arteriosus (PDA) following a single course of indomethacin in symptomatic preterm infants. Methods: This prospective observational study was carried out on 60 preterm infants weighing less than 1,750 g with symptomatic PDA confirmed by echocardiography. At a median age of 7.0 days (interquartile range 4.0), they were given indomethacin of 0.1 mg/kg/day intravenously daily for six days. Closure of PDA was reassessed by echocardiography upon completion of therapy. Results: The PDA of 40 percent (n=24) of these infants remained patent. Forward logistic regression analysis showed that the only significant predictors of failed PDA closure in these infants were: PDA size (adjusted odds-ratio [OR] is 7.0; 95 percent confidence interval [CI] of OR is 2.0, 24.8; p-value is 0.002), birth weight (adjusted OR is 0.996; 95 percent CI of OR is 0.993, 1.000; p-value is 0.03) and platelet count (adjusted OR is 0.987; 95 percent CI is 0.975, 1.000; p-value is 0.045). Gestational age, maternal age and left atrium/aorta ratios were not significant predictors. Conclusion: Larger PDA, lower birth weight and lower platelet count were significant predictors of high failure in indomethacin therapy given late at one week of life.

KW - Indomethacin therapy

KW - Patent ductus arteriosus

KW - Preterm infants

UR - http://www.scopus.com/inward/record.url?scp=33748607701&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748607701&partnerID=8YFLogxK

M3 - Article

C2 - 16924357

AN - SCOPUS:33748607701

VL - 47

SP - 763

EP - 768

JO - Singapore Medical Journal

JF - Singapore Medical Journal

SN - 0037-5675

IS - 9

ER -