Prediction of severe hyperbilirubinaemia using the Bilicheck transcutaneous bilirubinometer.

Nem Yun Boo, Shareena Ishak

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

OBJECTIVES: To determine the sensitivity and specificity of different levels of bilirubin measured by the transcutaneous bilirubinometer Bilicheck on forehead and sternum for predicting severe hyperbilirubinaemia of total serum bilirubin (TSB)>or=300 micromol/L in Malay, Chinese and Indian infants. DESIGN: A prospective observational study. SETTING: A tertiary care University hospital. METHODS: A total of 345 healthy jaundiced term infants were recruited prior to commencement of phototherapy or exchange transfusion. Transcutaneous bilirubin (TcB) level was measured with the Bilicheck from infants' foreheads (TcBh) and sternums (TcBs) within 30 min of serum bilirubin measurement by the diazo method in the hospital laboratory. RESULTS: The median serum TSB level of these infants was 233.0 micromol/L (range: 108.0-589.0). Ninety-five (27.5%) infants had TSB>or=300 micromol/L. There was good correlation between log10TSB and TcB measured from the forehead (r=0.80, P<0.0001) and the sternum (r=0.86, P<0.0001). At TcBh cut-off of 250 micromol/L, the Bilicheck detected TSB>or=300 micromol/L with a sensitivity of 100% and a specificity of 39.2%, the area under the receiver operative characteristic curve being 0.89 (95% confidence interval 0.85, 0.92). At TcBs cut-off of 200 micromol/L, the Bilicheck detected TSB>or=300 micromol/L with a sensitivity of 100% and a specificity of 33.6%, the area under receiver operative characteristic curve being 0.93 (95% confidence interval 0.90, 0.96). CONCLUSION: The Bilicheck is not a substitute for measuring serum bilirubin. However, using predetermined TcB cut-off values with reasonable sensitivity and specificity, it is a useful screening tool to identify infants with TSB>or=300 micromol/L requiring blood sampling, hospital admission and treatment.

Original languageEnglish
Pages (from-to)297-302
Number of pages6
JournalJournal of Paediatrics and Child Health
Volume43
Issue number4
DOIs
Publication statusPublished - Apr 2007

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Hyperbilirubinemia
Bilirubin
Serum
Forehead
Sternum
Confidence Intervals
Sensitivity and Specificity
Hospital Laboratories
Phototherapy
Tertiary Healthcare
Jaundice
Observational Studies
Prospective Studies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Prediction of severe hyperbilirubinaemia using the Bilicheck transcutaneous bilirubinometer. / Boo, Nem Yun; Ishak, Shareena.

In: Journal of Paediatrics and Child Health, Vol. 43, No. 4, 04.2007, p. 297-302.

Research output: Contribution to journalArticle

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title = "Prediction of severe hyperbilirubinaemia using the Bilicheck transcutaneous bilirubinometer.",
abstract = "OBJECTIVES: To determine the sensitivity and specificity of different levels of bilirubin measured by the transcutaneous bilirubinometer Bilicheck on forehead and sternum for predicting severe hyperbilirubinaemia of total serum bilirubin (TSB)>or=300 micromol/L in Malay, Chinese and Indian infants. DESIGN: A prospective observational study. SETTING: A tertiary care University hospital. METHODS: A total of 345 healthy jaundiced term infants were recruited prior to commencement of phototherapy or exchange transfusion. Transcutaneous bilirubin (TcB) level was measured with the Bilicheck from infants' foreheads (TcBh) and sternums (TcBs) within 30 min of serum bilirubin measurement by the diazo method in the hospital laboratory. RESULTS: The median serum TSB level of these infants was 233.0 micromol/L (range: 108.0-589.0). Ninety-five (27.5{\%}) infants had TSB>or=300 micromol/L. There was good correlation between log10TSB and TcB measured from the forehead (r=0.80, P<0.0001) and the sternum (r=0.86, P<0.0001). At TcBh cut-off of 250 micromol/L, the Bilicheck detected TSB>or=300 micromol/L with a sensitivity of 100{\%} and a specificity of 39.2{\%}, the area under the receiver operative characteristic curve being 0.89 (95{\%} confidence interval 0.85, 0.92). At TcBs cut-off of 200 micromol/L, the Bilicheck detected TSB>or=300 micromol/L with a sensitivity of 100{\%} and a specificity of 33.6{\%}, the area under receiver operative characteristic curve being 0.93 (95{\%} confidence interval 0.90, 0.96). CONCLUSION: The Bilicheck is not a substitute for measuring serum bilirubin. However, using predetermined TcB cut-off values with reasonable sensitivity and specificity, it is a useful screening tool to identify infants with TSB>or=300 micromol/L requiring blood sampling, hospital admission and treatment.",
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N2 - OBJECTIVES: To determine the sensitivity and specificity of different levels of bilirubin measured by the transcutaneous bilirubinometer Bilicheck on forehead and sternum for predicting severe hyperbilirubinaemia of total serum bilirubin (TSB)>or=300 micromol/L in Malay, Chinese and Indian infants. DESIGN: A prospective observational study. SETTING: A tertiary care University hospital. METHODS: A total of 345 healthy jaundiced term infants were recruited prior to commencement of phototherapy or exchange transfusion. Transcutaneous bilirubin (TcB) level was measured with the Bilicheck from infants' foreheads (TcBh) and sternums (TcBs) within 30 min of serum bilirubin measurement by the diazo method in the hospital laboratory. RESULTS: The median serum TSB level of these infants was 233.0 micromol/L (range: 108.0-589.0). Ninety-five (27.5%) infants had TSB>or=300 micromol/L. There was good correlation between log10TSB and TcB measured from the forehead (r=0.80, P<0.0001) and the sternum (r=0.86, P<0.0001). At TcBh cut-off of 250 micromol/L, the Bilicheck detected TSB>or=300 micromol/L with a sensitivity of 100% and a specificity of 39.2%, the area under the receiver operative characteristic curve being 0.89 (95% confidence interval 0.85, 0.92). At TcBs cut-off of 200 micromol/L, the Bilicheck detected TSB>or=300 micromol/L with a sensitivity of 100% and a specificity of 33.6%, the area under receiver operative characteristic curve being 0.93 (95% confidence interval 0.90, 0.96). CONCLUSION: The Bilicheck is not a substitute for measuring serum bilirubin. However, using predetermined TcB cut-off values with reasonable sensitivity and specificity, it is a useful screening tool to identify infants with TSB>or=300 micromol/L requiring blood sampling, hospital admission and treatment.

AB - OBJECTIVES: To determine the sensitivity and specificity of different levels of bilirubin measured by the transcutaneous bilirubinometer Bilicheck on forehead and sternum for predicting severe hyperbilirubinaemia of total serum bilirubin (TSB)>or=300 micromol/L in Malay, Chinese and Indian infants. DESIGN: A prospective observational study. SETTING: A tertiary care University hospital. METHODS: A total of 345 healthy jaundiced term infants were recruited prior to commencement of phototherapy or exchange transfusion. Transcutaneous bilirubin (TcB) level was measured with the Bilicheck from infants' foreheads (TcBh) and sternums (TcBs) within 30 min of serum bilirubin measurement by the diazo method in the hospital laboratory. RESULTS: The median serum TSB level of these infants was 233.0 micromol/L (range: 108.0-589.0). Ninety-five (27.5%) infants had TSB>or=300 micromol/L. There was good correlation between log10TSB and TcB measured from the forehead (r=0.80, P<0.0001) and the sternum (r=0.86, P<0.0001). At TcBh cut-off of 250 micromol/L, the Bilicheck detected TSB>or=300 micromol/L with a sensitivity of 100% and a specificity of 39.2%, the area under the receiver operative characteristic curve being 0.89 (95% confidence interval 0.85, 0.92). At TcBs cut-off of 200 micromol/L, the Bilicheck detected TSB>or=300 micromol/L with a sensitivity of 100% and a specificity of 33.6%, the area under receiver operative characteristic curve being 0.93 (95% confidence interval 0.90, 0.96). CONCLUSION: The Bilicheck is not a substitute for measuring serum bilirubin. However, using predetermined TcB cut-off values with reasonable sensitivity and specificity, it is a useful screening tool to identify infants with TSB>or=300 micromol/L requiring blood sampling, hospital admission and treatment.

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