Preconditioning as a potential strategy for the prevention of Parkinson's disease

Mojtaba Golpich, Behrouz Rahmani, Norlinah Mohamed Ibrahim, Leila Dargahi, Zahurin Mohamed, Azman Ali Raymond, Abolhassan Ahmadiani

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12 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a chronic neurodegenerative movement disorder characterized by the progressive and massive loss of dopaminergic neurons by neuronal apoptosis in the substantia nigra pars compacta and depletion of dopamine in the striatum, which lead to pathological and clinical abnormalities. A numerous of cellular processes including oxidative stress, mitochondrial dysfunction, and accumulation of α-synuclein aggregates are considered to contribute to the pathogenesis of Parkinson's disease. A further understanding of the cellular and molecular mechanisms involved in the pathophysiology of PD is crucial for developing effective diagnostic, preventative, and therapeutic strategies to cure this devastating disorder. Preconditioning (PC) is assumed as a natural adaptive process whereby a subthreshold stimulus can promote protection against a subsequent lethal stimulus in the brain as well as in other tissues that affords robust brain tolerance facing neurodegenerative insults. Multiple lines of evidence have demonstrated that preconditioning as a possible neuroprotective technique may reduce the neural deficits associated with neurodegenerative diseases such as PD. Throughout the last few decades, a lot of efforts have been made to discover the molecular determinants involved in preconditioning-induced protective responses; although, the accurate mechanisms underlying this "tolerance" phenomenon are not fully understood in PD. In this review, we will summarize pathophysiology and current therapeutic approaches in PD and discuss about preconditioning in PD as a potential neuroprotective strategy. Also the role of gene reprogramming and mitochondrial biogenesis involved in the preconditioning-mediated neuroprotective events will be highlighted. Preconditioning may represent a promising therapeutic weapon to combat neurodegeneration.

Original languageEnglish
Pages (from-to)313-330
Number of pages18
JournalMolecular Neurobiology
Volume51
Issue number1
DOIs
Publication statusPublished - 1 Feb 2015

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Parkinson Disease
Neurodegenerative Diseases
Synucleins
Weapons
Dopaminergic Neurons
Movement Disorders
Brain
Organelle Biogenesis
Dopamine
Oxidative Stress
Therapeutics
Apoptosis
Genes

ASJC Scopus subject areas

  • Medicine(all)

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Preconditioning as a potential strategy for the prevention of Parkinson's disease. / Golpich, Mojtaba; Rahmani, Behrouz; Mohamed Ibrahim, Norlinah; Dargahi, Leila; Mohamed, Zahurin; Raymond, Azman Ali; Ahmadiani, Abolhassan.

In: Molecular Neurobiology, Vol. 51, No. 1, 01.02.2015, p. 313-330.

Research output: Contribution to journalArticle

Golpich, Mojtaba ; Rahmani, Behrouz ; Mohamed Ibrahim, Norlinah ; Dargahi, Leila ; Mohamed, Zahurin ; Raymond, Azman Ali ; Ahmadiani, Abolhassan. / Preconditioning as a potential strategy for the prevention of Parkinson's disease. In: Molecular Neurobiology. 2015 ; Vol. 51, No. 1. pp. 313-330.
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