Precocious puberty in children: A review of imaging findings

Faizah Mohd Zaki, A. H. Zuhanis, Rahmah Rasat, A. A. Raja, Loo Ling Wu, Dayang Anita Abdul Aziz, M. A. Zulfiqar

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives: This review was aimed at determining the imaging findings in patients with precocious puberty. Results: Within a period of 8 years (from 2002 to 2010) there were 53 patients diagnosed with precocious puberty. Out of the 53 patients, 37 had undergone diagnostic imaging to detect the possible organic causes of precocious puberty. Imaging findings were positive in 31 patients and out of that, 3 patients had 2 findings each (34 abnormalities). Of the patients with positive imaging findings, central precocious puberty (gonadotrophin-dependent) was more common (81%; 25/31) and the causes included: tuber cinereum hamartoma (n = 10), glioma (n = 6), pineal gland tumour (n = 4), hydrocephalous (n = 3), arachnoid cyst (n = 2) and others (n = 3). Peripheral precocious puberty (gonadotrophin-independent) causes included: testicular adrenal rest tumour (n = 3), adrenal carcinoma (n = 1), ovarian granulosa thecal cell tumour (n = 1), and tuberous sclerosis (n = 1). Conclusion: Positive imaging findings were observed in 84% (31/37) of the subjects. Hypothalamic hamartoma was the most common imaging finding in central precocious puberty while testicular adrenal rest tumour was the most common imaging finding in peripheral precocious puberty.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalBiomedical Imaging and Intervention Journal
Volume8
Issue number1
DOIs
Publication statusPublished - 2012

Fingerprint

Precocious Puberty
Imaging techniques
Adrenal Rest Tumor
Tumors
Testicular Neoplasms
Tuber Cinereum
Pinealoma
Granulosa Cell Tumor
Arachnoid Cysts
Hamartoma
Diagnostic Imaging
Gonadotropins
Glioma
Carcinoma

Keywords

  • Imaging
  • Precocious puberty

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Precocious puberty in children : A review of imaging findings. / Mohd Zaki, Faizah; Zuhanis, A. H.; Rasat, Rahmah; Raja, A. A.; Wu, Loo Ling; Abdul Aziz, Dayang Anita; Zulfiqar, M. A.

In: Biomedical Imaging and Intervention Journal, Vol. 8, No. 1, 2012, p. 1-8.

Research output: Contribution to journalArticle

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