Prealbumin rather than albumin is a more sensitive indicator of acute liver disease.

Yasmin Anum Mohd Yusof, B. Aziz, M. Nazim, R. K. Madhavan

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The changes in serum prealbumin (transthyretin) and serum albumin in acute and chronic liver diseases were investigated. Albumin has long been used as a useful indicator of liver function but serum prealbumin has recently been noted for its clinical significance in acute liver diseases. Serum prealbumin concentrations and liver function tests (albumin, bilirubin, alanine aminotransferase) were determined on blood obtained from normal donors (n = 148) and from patients suffering from liver diseases (n = 78) such as acute viral hepatitis, chronic active hepatitis, cirrhosis and hepatoma. The mean serum prealbumin concentration in normal subjects was 29.6 +/- 4.82 mg/dl while the mean serum prealbumin concentration in patients with liver disease was greatly reduced (acute viral hepatitis = 15.3 +/- 7.4mg/dl; chronic active hepatitis = 10.2 +/- 6.6mg/dl; cirrhosis = 9.9 +/- 6.4mg/dl and hepatoma = 10.7 +/- 4.2). Albumin concentrations dropped slightly (13% compared to control) in acute viral hepatitis but dropped markedly (28% compared to control) in chronic liver diseases. The study suggests that serum prealbumin concentration might be a more sensitive indicator than albumin in assessing liver dysfunction in acute liver diseases.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalThe Malaysian journal of pathology
Volume15
Issue number2
Publication statusPublished - Dec 1993
Externally publishedYes

Fingerprint

Prealbumin
Acute Disease
Liver Diseases
Albumins
Serum
Hepatitis
Chronic Hepatitis
Hepatocellular Carcinoma
Fibrosis
Chronic Disease
Liver Function Tests
Alanine Transaminase
Bilirubin
Serum Albumin
Tissue Donors
Liver

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Medicine(all)
  • Cell Biology

Cite this

Mohd Yusof, Y. A., Aziz, B., Nazim, M., & Madhavan, R. K. (1993). Prealbumin rather than albumin is a more sensitive indicator of acute liver disease. The Malaysian journal of pathology, 15(2), 147-150.

Prealbumin rather than albumin is a more sensitive indicator of acute liver disease. / Mohd Yusof, Yasmin Anum; Aziz, B.; Nazim, M.; Madhavan, R. K.

In: The Malaysian journal of pathology, Vol. 15, No. 2, 12.1993, p. 147-150.

Research output: Contribution to journalArticle

Mohd Yusof, YA, Aziz, B, Nazim, M & Madhavan, RK 1993, 'Prealbumin rather than albumin is a more sensitive indicator of acute liver disease.', The Malaysian journal of pathology, vol. 15, no. 2, pp. 147-150.
Mohd Yusof, Yasmin Anum ; Aziz, B. ; Nazim, M. ; Madhavan, R. K. / Prealbumin rather than albumin is a more sensitive indicator of acute liver disease. In: The Malaysian journal of pathology. 1993 ; Vol. 15, No. 2. pp. 147-150.
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