Pre-initiation effect of oleuropein towards apoptotic and oxidative stress levels on the early development of two-stage skin carcinogenesis

Dayang Noor Suzliana John, Tengku Hasmira Tengku Mamat, Omchit Surien, Taib Izatus Shima, Siti Fathiah Masre

Research output: Contribution to journalArticle

Abstract

Background: Oleuropein is a form of phenolic compound which can be majorly found in the olive leaves. Previous studies have shown several biological functions of oleuropein against different cancer cells. Aim and Objectives: This research was designed to study the pre-initiation effect of oleuropein on the early skin tumour development using a mouse model. Material and Methods: Female Institute of Cancer Research (ICR) mice (n=6 per group) were divided into 2 groups (group 1 as a carcinogen control and group 2 as a vehicle control) and 1 treatment group (group 3: 10 mg/kg of oleuropein). Results:After 10 weeks, Group 3 showed delay in epidermal hyperplasia formation and a significant reduction (p<0.05) in the epidermal thickness as compared to Group 1. Data were also displayed a significant increase (p<0.05) in the apoptotic rate in Group 3 as compared to Group 1 and 2. For biochemical assays, the level of Malondialdehyde (MDA) was significantly (p<0.05) decreased whilst the levels of Glutathione (GSH) and Superoxide Dismutase (SOD) were significantly (p<0.05) increased in Group 3 as compared to Group 1. Conclusion: Our results indicate that pre-initiation treatment of oleuropein may prevent skin tumour development through its antioxidant and apoptotic activities.

Original languageEnglish
Pages (from-to)43-51
Number of pages9
JournalJournal of Krishna Institute of Medical Sciences University
Volume8
Issue number1
Publication statusPublished - 1 Jan 2019

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Carcinogenesis
Oxidative Stress
Skin
Neoplasms
Olea
Malondialdehyde
Carcinogens
Superoxide Dismutase
Hyperplasia
Glutathione
Antioxidants
oleuropein
Control Groups
Research

Keywords

  • Carcinogenesis
  • Chemoprevention
  • Oleuropein
  • Olive
  • Skin Cancer

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pre-initiation effect of oleuropein towards apoptotic and oxidative stress levels on the early development of two-stage skin carcinogenesis. / John, Dayang Noor Suzliana; Mamat, Tengku Hasmira Tengku; Surien, Omchit; Izatus Shima, Taib; Masre, Siti Fathiah.

In: Journal of Krishna Institute of Medical Sciences University, Vol. 8, No. 1, 01.01.2019, p. 43-51.

Research output: Contribution to journalArticle

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AU - Mamat, Tengku Hasmira Tengku

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AU - Izatus Shima, Taib

AU - Masre, Siti Fathiah

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