Potential secondary metabolites from marine sponge Aaptos aaptos for atherosclerosis and vibriosis treatments

Habsah Mohamad, Rosmiati, Tengku Sifzizul Tengku Muhammad, Yosie Andriani, Kamariah Bakar, Noraznawati Ismail, Jasnizat Saidin, Jalifah Latip, Najiah Musa, Andi Parenrengi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Natural products play a crucial role in drug discovery. In the last decade, the advent of marine natural product research has produced a remarkable number of compounds, particularly those isolated from marine sponges, with a broad range of activities for the treatment of human and animal diseases. In this study, five known alkaloids namely aaptamine (1), 9-demethylaaptamine (2), 4-N-methylaaptamine (3), 9-methoxyaaptamine (4), 9-demethyloxyaaptamine (5), an uncommon amide in sponge, 4-hydroxybenzamide (6) and 3 β,5α -cholesterol (7) were isolated from the butanol extract of Aaptos aaptos (Schmidt, 1864) by bioactivity-guided isolation. Their structures were determined based on a detailed analysis of their 1D and 2D spectroscopic NMR and EIMS spectral data as well as comparison with literature data. Cytotoxic activity and anti-atherosclerotic property of the compounds were determined based on their ability to increase the transcriptional activity of SRB1 promoter and PPRE in human liver HepG2 cell line. The results showed that compounds 4 and 7 exhibited cytotoxic effects and compounds 1-4 and 7 increased the transcriptional activity of SRB1 promoter and PPRE. This suggests that compounds isolated from A. aaptos may have potential as anti-cancer agents and to reduce the progression of atherosclerosis. In addition, the compounds 1-4 displayed antibacterial activity against shrimp pathogenic bacteria, Vibrio harveyi and Vibrio sp. This suggests that the compounds have potential as vibriosis treatment.

Original languageEnglish
Pages (from-to)1227-1230
Number of pages4
JournalNatural Product Communications
Volume12
Issue number8
Publication statusPublished - 2017

Fingerprint

Aaptos aaptos
vibriosis
Vibrio
Porifera
Biological Products
atherosclerosis
secondary metabolites
Atherosclerosis
promoter regions
diseases and disorders (animals and humans)
Vibrio harveyi
Animal Diseases
Butanols
antineoplastic agents
Hep G2 Cells
Drug Discovery
butanol
amides
Alkaloids
Human Activities

Keywords

  • 4-Hydroxybezamide
  • Aaptaminoids
  • Aaptos aaptos
  • Alkaloid
  • Atherosclerosis
  • Marine sponge
  • PPAR
  • SRB1
  • Vibriosis

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Mohamad, H., Rosmiati, Muhammad, T. S. T., Andriani, Y., Bakar, K., Ismail, N., ... Parenrengi, A. (2017). Potential secondary metabolites from marine sponge Aaptos aaptos for atherosclerosis and vibriosis treatments. Natural Product Communications, 12(8), 1227-1230.

Potential secondary metabolites from marine sponge Aaptos aaptos for atherosclerosis and vibriosis treatments. / Mohamad, Habsah; Rosmiati; Muhammad, Tengku Sifzizul Tengku; Andriani, Yosie; Bakar, Kamariah; Ismail, Noraznawati; Saidin, Jasnizat; Latip, Jalifah; Musa, Najiah; Parenrengi, Andi.

In: Natural Product Communications, Vol. 12, No. 8, 2017, p. 1227-1230.

Research output: Contribution to journalArticle

Mohamad, H, Rosmiati, Muhammad, TST, Andriani, Y, Bakar, K, Ismail, N, Saidin, J, Latip, J, Musa, N & Parenrengi, A 2017, 'Potential secondary metabolites from marine sponge Aaptos aaptos for atherosclerosis and vibriosis treatments', Natural Product Communications, vol. 12, no. 8, pp. 1227-1230.
Mohamad H, Rosmiati, Muhammad TST, Andriani Y, Bakar K, Ismail N et al. Potential secondary metabolites from marine sponge Aaptos aaptos for atherosclerosis and vibriosis treatments. Natural Product Communications. 2017;12(8):1227-1230.
Mohamad, Habsah ; Rosmiati ; Muhammad, Tengku Sifzizul Tengku ; Andriani, Yosie ; Bakar, Kamariah ; Ismail, Noraznawati ; Saidin, Jasnizat ; Latip, Jalifah ; Musa, Najiah ; Parenrengi, Andi. / Potential secondary metabolites from marine sponge Aaptos aaptos for atherosclerosis and vibriosis treatments. In: Natural Product Communications. 2017 ; Vol. 12, No. 8. pp. 1227-1230.
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