Potential immunosuppressive and antiinflammatory activities of Malaysian medicinal plants characterized by reduced cell surface expression of cell adhesion molecules

Shigeo Tanaka, Sakata Yoichi, Lixi Ao, Mariko Matumoto, Katsushi Morimoto, Naoshige Akimoto, Gisho Honda, Mamoru Tabata, Tikashi Oshima, Toru Masuda, Mohd Zaini Bin Asmawi, Zhari Ismail, Sharom Mohd Yusof, Laily B. Din, Ikram M. Said

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Abstract

    In the search for agents effective against immune-mediated disorders and inflammation, we have screened Malaysian medicinal plants for the ability to inhibit the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the surface of murine endothelial cells (F-2), and mouse myeloid leukaemia cells (M1), respectively. Of 41 kinds (29 species, 24 genera, 16 families) of Malaysian plants tested, 10 and 19 plant samples significantly downregulated the expression of ICAM-1 and VCAM-1, respectively. Bioassay-directed fractionation of an extract prepared from the bark of Goniothalamus andersonii showed that its ingredients, goniothalamin (1) and goniodiol (2) inhibited the cell surface expression of both ICAM-1 and VCAM-1. The present results suggest that Malaysian medicinal plants may be abundant natural resources for immunosuppressive and antiinflammatory substances.

    Original languageEnglish
    Pages (from-to)681-686
    Number of pages6
    JournalPhytotherapy Research
    Volume15
    Issue number8
    DOIs
    Publication statusPublished - 2001

    Fingerprint

    Vascular Cell Adhesion Molecule-1
    Cell Adhesion Molecules
    Intercellular Adhesion Molecule-1
    Immunosuppressive Agents
    Medicinal Plants
    Anti-Inflammatory Agents
    Goniothalamus
    Myeloid Leukemia
    Bioassay
    Immune System Diseases
    Endothelial cells
    Natural resources
    Myeloid Cells
    Fractionation
    Biological Assay
    Down-Regulation
    Endothelial Cells
    Inflammation

    Keywords

    • Antiinflammatory
    • Cell adhesion molecule
    • Goniodiol
    • Goniothalamin
    • Immunosuppressive
    • Malaysian medicinal plant

    ASJC Scopus subject areas

    • Drug Discovery
    • Organic Chemistry
    • Pharmacology

    Cite this

    Potential immunosuppressive and antiinflammatory activities of Malaysian medicinal plants characterized by reduced cell surface expression of cell adhesion molecules. / Tanaka, Shigeo; Yoichi, Sakata; Ao, Lixi; Matumoto, Mariko; Morimoto, Katsushi; Akimoto, Naoshige; Honda, Gisho; Tabata, Mamoru; Oshima, Tikashi; Masuda, Toru; Asmawi, Mohd Zaini Bin; Ismail, Zhari; Yusof, Sharom Mohd; Din, Laily B.; Said, Ikram M.

    In: Phytotherapy Research, Vol. 15, No. 8, 2001, p. 681-686.

    Research output: Contribution to journalArticle

    Tanaka, S, Yoichi, S, Ao, L, Matumoto, M, Morimoto, K, Akimoto, N, Honda, G, Tabata, M, Oshima, T, Masuda, T, Asmawi, MZB, Ismail, Z, Yusof, SM, Din, LB & Said, IM 2001, 'Potential immunosuppressive and antiinflammatory activities of Malaysian medicinal plants characterized by reduced cell surface expression of cell adhesion molecules', Phytotherapy Research, vol. 15, no. 8, pp. 681-686. https://doi.org/10.1002/ptr.778
    Tanaka, Shigeo ; Yoichi, Sakata ; Ao, Lixi ; Matumoto, Mariko ; Morimoto, Katsushi ; Akimoto, Naoshige ; Honda, Gisho ; Tabata, Mamoru ; Oshima, Tikashi ; Masuda, Toru ; Asmawi, Mohd Zaini Bin ; Ismail, Zhari ; Yusof, Sharom Mohd ; Din, Laily B. ; Said, Ikram M. / Potential immunosuppressive and antiinflammatory activities of Malaysian medicinal plants characterized by reduced cell surface expression of cell adhesion molecules. In: Phytotherapy Research. 2001 ; Vol. 15, No. 8. pp. 681-686.
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