Post transplant lymphoproliferative disorder

A case series and review of literature

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: Post-transplant lymphoproliferative disorder (PTLD) is a recognized complication exclusive to solid organ transplant recipients and carries a high mortality. Methods: We retrospectively reviewed records of all renal transplant recipients under follow up at our institution over the last seven years (2005-2011). We reviewed the patient characteristics, immunosuppression regimen and risk factors for the development of PTLD and its outcomes in our transplant cohort. Results: Four out of 63 patients were diagnosed with PTLD. PTLD was incidentally diagnosed on a transplant biopsy that was performed for an unexplained rise in serum creatinine in three patients. The fourth patient presented with left submandibular lymphadenopathy. Majority presented within 18 months of renal transplantation. After the diagnosis of PTLD on graft biopsy, all patients were fully investigated and two patients had systemic involvement. In the patients with systemic involvement, reduction of immunosuppression and anti B cell therapy with Rituximab was used with good success. The patient with submandibular lymphadenopathy received chemotherapy in addition to reduction of immunosuppression. Three PTLD cases were polyclonal and diagnosed early whereas the fourth case was monoclonal. Conclusion: PTLD can sometimes be incidentally diagnosed on an allograft biopsy performed for rejection. The incidence of PTLD in our centre is higher than reports from other centres but our outcome is good if recognised and treated early.

Original languageEnglish
Pages (from-to)144-149
Number of pages6
JournalEXCLI Journal
Volume12
Publication statusPublished - 25 Feb 2013

Fingerprint

lymphatic diseases
Lymphoproliferative Disorders
Transplants
immunosuppression
biopsy
kidney transplant
Immunosuppression
Biopsy
organ transplantation
allografting
creatinine
drug therapy
B-lymphocytes
Cell- and Tissue-Based Therapy
risk factors
Kidney Transplantation
Allografts
Creatinine
B-Lymphocytes
incidence

Keywords

  • Epstein-Barr virus
  • Immunosuppression reduction
  • Post transplant lymphoproliferative disorder
  • Renal transplantation

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Animal Science and Zoology

Cite this

Post transplant lymphoproliferative disorder : A case series and review of literature. / Abdul Cader, Rizna; Mohd, Rozita; Abdul Gafor, Abdul Halim; Kong, Norella C T.

In: EXCLI Journal, Vol. 12, 25.02.2013, p. 144-149.

Research output: Contribution to journalArticle

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