Polysaccharide-based superporous, superabsorbent, and stimuli responsive hydrogel from sweet Basil

A novel material for sustained drug release

Bilal Ahmad Lodhi, Muhammad Ajaz Hussain, Muhammad Sher, Muhammad Tahir Haseeb, Muhammad Umer Ashraf, Syed Zajif Hussain, Irshad Hussain, Bukhari Syed Nasir Abbas

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study is carried out on polysaccharide-based hydrogel extracted from the seeds of Ocimum basilicum L. for its evaluation as a superabsorbent and stimuli responsive biomaterial for sustained release drug delivery system. O. basilicum (Syn: Basil) seed hydrogel (BSH) expressed high swelling capacity at pH 6.8 and 7.4 and deionized water. Highly reversible on-off switching (swelling-deswelling) behavior of BSH was ascertained in deionized water and ethanol, pH 7.4 and 1.2, and deionized water and normal saline. Scanning electron microscopy (SEM) of BSH has revealed macroporous structure of BSH having average pore size of 1.92 ± 3.83 m noted after swelling and lyophilization. BSH containing tablet formulations showed a sustained release pattern of diclofenac sodium (DS) which is dependent on the concentration of BSH. When comparing with commercially available formulation of DS, even better sustained release behavior of DS was observed in BSH-based formulation. Super case-II transport mechanism is followed by the DS release from BSH matrix tablet. Haemocompatibility studies of BSH were also performed and found it nonhaemolytic and nonthrombogenic.

Original languageEnglish
Article number9583516
JournalAdvances in Polymer Technology
Volume2019
DOIs
Publication statusPublished - 1 Jan 2019
Externally publishedYes

Fingerprint

Hydrogel
Polysaccharides
Hydrogels
Seed
Pharmaceutical Preparations
Diclofenac
Deionized water
Sodium
Swelling
Tablets
Biocompatible Materials
Biomaterials
Pore size
Ethanol
Scanning electron microscopy

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics

Cite this

Polysaccharide-based superporous, superabsorbent, and stimuli responsive hydrogel from sweet Basil : A novel material for sustained drug release. / Lodhi, Bilal Ahmad; Hussain, Muhammad Ajaz; Sher, Muhammad; Haseeb, Muhammad Tahir; Ashraf, Muhammad Umer; Hussain, Syed Zajif; Hussain, Irshad; Syed Nasir Abbas, Bukhari.

In: Advances in Polymer Technology, Vol. 2019, 9583516, 01.01.2019.

Research output: Contribution to journalArticle

Lodhi, Bilal Ahmad ; Hussain, Muhammad Ajaz ; Sher, Muhammad ; Haseeb, Muhammad Tahir ; Ashraf, Muhammad Umer ; Hussain, Syed Zajif ; Hussain, Irshad ; Syed Nasir Abbas, Bukhari. / Polysaccharide-based superporous, superabsorbent, and stimuli responsive hydrogel from sweet Basil : A novel material for sustained drug release. In: Advances in Polymer Technology. 2019 ; Vol. 2019.
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