Polysaccharide-based materials in macromolecular prodrug design and development

M. A. Hussain, K. Abbas, Ibrahim Jantan, Bukhari Syed Nasir Abbas

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This review summarises the recent efforts to engineer macromolecular prodrugs (MPDs) based on polysaccharidal materials. Polysaccharidal materials are of utmost importance to design and develop MPDs of non-steroidal anti-inflammatory drugs, antibiotics, anti-viral and anti-cancer drugs, etc. Covalent drug loading capabilities of the polysaccharidal materials are thoroughly discussed. In order to successfully transform drugs into prodrugs using polysaccharidal materials, present review details different syntheses strategies which are being applied to design pharmaceutically viable MPDs. Herein, we also reported the collection of polysaccharidal materials which are being widely spun in to MPDs of several classes of drugs and their applications. Merits and demerits of polysaccharide biomaterials for MPDs are critically discussed. Cellulose ether derivatives are newly introduced materials attracting the vigil eye of researchers working in MPD design for potential therapeutic applications. Special emphasis will be given to amphiphilic materials, i.e. MPDs, which self-assemble at solvent interfaces into nanorods, nanoparticles (NPs), nanowires, etc. Furthermore, the stability of MPDs at elevated conditions of temperature is discussed to gain information about their storage properties. We highlighted thrust areas in polysaccharidal materials-based research and development of MPDs.

Original languageEnglish
Pages (from-to)1-21
Number of pages21
JournalInternational Materials Reviews
DOIs
Publication statusAccepted/In press - 26 Jul 2016

Fingerprint

Prodrugs
Polysaccharides
Pharmaceutical Preparations
Antibiotics
Nanorods
Biomaterials
Nanowires
Biocompatible Materials
Ethers
Cellulose
Ether
Nanoparticles
Derivatives
Engineers
Anti-Inflammatory Agents
Anti-Bacterial Agents

Keywords

  • Cellulose ethers
  • Dextran
  • Drug design
  • Macromolecular prodrugs
  • Nanoassemblies
  • Polysaccharides
  • Prodrugs

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Materials Chemistry
  • Metals and Alloys

Cite this

Polysaccharide-based materials in macromolecular prodrug design and development. / Hussain, M. A.; Abbas, K.; Jantan, Ibrahim; Syed Nasir Abbas, Bukhari.

In: International Materials Reviews, 26.07.2016, p. 1-21.

Research output: Contribution to journalArticle

Hussain, M. A. ; Abbas, K. ; Jantan, Ibrahim ; Syed Nasir Abbas, Bukhari. / Polysaccharide-based materials in macromolecular prodrug design and development. In: International Materials Reviews. 2016 ; pp. 1-21.
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