Polymorphism of the serotonin transporter gene (5-HTTLPR) in major depressive disorder patients in Malaysia

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: The serotonin transporter promoter (5-HTTLPR) is a potential susceptibility locus in the pathogenesis of major depressive disorder. However, data from Malaysia is lacking. The present study aimed to determine the association between the homozygous short variant of the serotonin transporter promoter gene (5-HTTLPR) with major depressive disorder. Methods: This is a candidate gene case-control association study. The sample consists of 55 major depressive disorder probands and 66 controls. They were Malaysian descents and were unrelated. The Axis I diagnosis was determined using Mini International Neuropsychiatric Interview (M.I.N.I.). The control group comprised healthy volunteers without personal psychiatric history and family history of mood disorders. Participants' blood was sent to the Institute Medical Research for genotyping. Results: The present study failed to detect an association between 5-HTTLPR ss genotype with major depressive disorder (χ 2=3.67, d.f.=1, P=0.055, odds ratio 0.25, 95% confidence interval=0.07-1.94). Sub-analysis revealed that the frequency of l allele in healthy controls was higher (78.0%) than that of Caucasian and East Asian population. However, in view of the small sample size this study may be prone to type II error (and type I error). Discussion: This preliminary study suggests that the homozygous short variant of the 5-HTTLPR did not appear to be a risk factor for increasing susceptibility to major depressive disorder.

Original languageEnglish
Pages (from-to)126-130
Number of pages5
JournalAsia-Pacific Psychiatry
Volume4
Issue number2
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Malaysia
Major Depressive Disorder
Genes
Mood Disorders
Gene Frequency
Sample Size
Psychiatry
Case-Control Studies
Biomedical Research
Healthy Volunteers
Odds Ratio
Genotype
Confidence Intervals
Interviews
Control Groups
Population

Keywords

  • 5-HTTLPR
  • Affective disorder
  • Candidate gene association study
  • Major depressive disorder
  • Serotonin transporter

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Polymorphism of the serotonin transporter gene (5-HTTLPR) in major depressive disorder patients in Malaysia. / Mohamed Saini, Suriati; Muhamad Radzi, Azizah; Abdul Rahman, Abdul Hamid.

In: Asia-Pacific Psychiatry, Vol. 4, No. 2, 06.2012, p. 126-130.

Research output: Contribution to journalArticle

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