Polymorphism of 11 Y Chromosome Short Tandem Repeat Markers among Malaysian Aborigines

Sofia Sakina Mohd Yussup, Marlia Marzukhi, Badrul Munir Md. Zain, Kamaruddin Mamat, Farida Zuraina Mohd Yusof

Research output: Contribution to journalArticle

Abstract

The conventional technique such as patrilocality suggests some substantial effects on population diversity. With that, this particular study investigated the paternal line, specifically Scientific Working Group on DNA Analysis Methods (SWGDAM)-recommended Y-STR markers, namely, DYS19, DYS385, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS438, and DYS439. These markers were tested to compare 184 Orang Asli individuals from 3 tribes found in Peninsular Malaysia. As a result, the haplotype diversity and the discrimination capacity obtained were 0.9987 and 0.9076, respectively. Besides, the most diverse marker was DYS385b, whereas the least was DYS391. Furthermore, the Senoi and Proto-Malay tribes were found to be the most distant, whereas the Senoi and Negrito clans were almost similar to each other. In addition, the analysis of molecular variance analysis revealed 82% of variance within the population, but only 18% of difference between the tribes. Finally, the phylogenetic trees constructed using Neighbour Joining and UPGMA (Unweighted Pair Group Method with Arithmetic Mean) displayed several clusters that were tribe specific. With that, future studies are projected to analyse individuals based on more specific sub-tribes.

Original languageEnglish
JournalEvolutionary Bioinformatics
Volume13
DOIs
Publication statusPublished - 10 Jul 2017

Fingerprint

tribal peoples
indigenous peoples
Y Chromosome
Y chromosome
Chromosomes
Polymorphism
Joining
Microsatellite Repeats
chromosome
Analysis of Variance
polymorphism
DNA
genetic polymorphism
microsatellite repeats
Malaysia
Haplotypes
Population
variance analysis
phylogenetics
haplotypes

Keywords

  • Negrito
  • Orang Asli
  • Peninsular Malaysia
  • Senoi
  • Y-STR

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Computer Science Applications

Cite this

Polymorphism of 11 Y Chromosome Short Tandem Repeat Markers among Malaysian Aborigines. / Mohd Yussup, Sofia Sakina; Marzukhi, Marlia; Md. Zain, Badrul Munir; Mamat, Kamaruddin; Mohd Yusof, Farida Zuraina.

In: Evolutionary Bioinformatics, Vol. 13, 10.07.2017.

Research output: Contribution to journalArticle

Mohd Yussup, Sofia Sakina ; Marzukhi, Marlia ; Md. Zain, Badrul Munir ; Mamat, Kamaruddin ; Mohd Yusof, Farida Zuraina. / Polymorphism of 11 Y Chromosome Short Tandem Repeat Markers among Malaysian Aborigines. In: Evolutionary Bioinformatics. 2017 ; Vol. 13.
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