Pluronic-F127 composite film loaded with erythromycin for wound application: formulation, physicomechanical and in vitro evaluations

Taradokht Alavi, Masoud Rezvanian, Naveed Ahmad, Najwa Mohamad, Shiow Fern Ng

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Composite film dressings composed of pluronic F127 (PL)–pectin (PC) and pluronic (PL) F127–gelatin (GL) were investigated as potential drug delivery system for wound healing. Composite films were solvent cast by blending PL with PC or GL in different ratios using glycerol (2.5%) as plasticizer. Erythromycin (ER) (0.1%) was incorporated in films as model hydrophobic antibiotic. The optimized composite films were characterized for physical appearance, morphology, mechanical profile, and thermal behavior. In addition, drug release, antibacterial activity, and cytocompatibility of the films were investigated to assess their potential as drug delivery system. The composite films exhibited excellent wound dressing characters in terms of appearance, stability, and mechanical profile. Moreover, ER-loaded composite films released ER in controlled manner, exhibited antibacterial activity against Staphylococcus aureus, and were non-toxic to human skin fibroblast. These findings demonstrate that these composite films hold the potential to be formulated as antibacterial wound dressing.

Original languageEnglish
Pages (from-to)508-519
Number of pages12
JournalDrug Delivery and Translational Research
Volume9
Issue number2
DOIs
Publication statusPublished - 15 Apr 2019

Fingerprint

UCON 50-HB-5100
Poloxamer
Erythromycin
Bandages
Wounds and Injuries
Drug Delivery Systems
Plasticizers
Wound Healing
Glycerol
Staphylococcus aureus
Fibroblasts
Hot Temperature
Anti-Bacterial Agents
Skin
In Vitro Techniques

Keywords

  • Erythromycin
  • Gelatin
  • Pectin
  • Pluronic
  • Wound dressing

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Pluronic-F127 composite film loaded with erythromycin for wound application : formulation, physicomechanical and in vitro evaluations. / Alavi, Taradokht; Rezvanian, Masoud; Ahmad, Naveed; Mohamad, Najwa; Ng, Shiow Fern.

In: Drug Delivery and Translational Research, Vol. 9, No. 2, 15.04.2019, p. 508-519.

Research output: Contribution to journalArticle

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