Plexiform schwannoma of the clitoris in a young girl: A case report

Nur Azurah Abdul Ghani, Sonia Grover, Duncan McGregor

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Schwannoma (neurilemoma) is a benign, slow-growing tumor of the nerve sheath. These tumors are rarely found in the female genitalia and to date only 1 case of clitoral schwannoma has been refocal Verocay body-like structures were found. There was mild to moderate pleomorphism. No mitotic figures were identified. There was diffuse staining of interweaving bundles for S100 protein and glial fibrillary acidic ported in a young girl. We report here the second case of schwannoma of the clitoris. CASE: A 6-year-old girl presented with an enlarging clitoris. An alteration in her clitoral appearance had first protein without staining for actin, desmin, or neurofilament. These features are consistent with a plexiform schwannoma. CONCLUSION: Although benign schwannomas rarely been noted at 2 years of age. However, the size had further increased in the year prior to presentation. On examination her clitoris was normal in size but beneath the clitoral hood, predominantly on the left, there was a 3 × 2 cm irregular mobile mass. Her karyotype revealed normal 46XX female genotype. Magnetic resonance imaging of the abdomen and pelvis showed an isolated finding of diffuse enlargement of the clitoris with edema of the mons pubis. Surgical excision of the paraclitoral mass was performed. Intraoperatively the clitoral tip and shaft did not appear to be involved. However, the mass was found to be more diffuse, less well-defined, and more extensive than the clinical findings had suggested. On histology long spindle cells with nuclear palisading and occur in the clitoris, we suggest that it should be considered as differential diagnosis for any young girl with clitoral or paraclitoral asymmetrical irregular mass.

Original languageEnglish
Pages (from-to)365-368
Number of pages4
JournalJournal of Reproductive Medicine
Volume58
Issue number7-8
Publication statusPublished - Aug 2013
Externally publishedYes

Fingerprint

Clitoris
Neurilemmoma
Pubic Bone
Nerve Sheath Neoplasms
Staining and Labeling
Female Genitalia
Desmin
Intermediate Filaments
S100 Proteins
Pelvis
Karyotype
Neuroglia
Abdomen
Actins
Edema
Histology
Differential Diagnosis
Genotype
Magnetic Resonance Imaging

Keywords

  • Clitoris
  • Neurilemoma
  • Plexiform
  • Schwannoma
  • Schwannomatosis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Plexiform schwannoma of the clitoris in a young girl : A case report. / Abdul Ghani, Nur Azurah; Grover, Sonia; McGregor, Duncan.

In: Journal of Reproductive Medicine, Vol. 58, No. 7-8, 08.2013, p. 365-368.

Research output: Contribution to journalArticle

Abdul Ghani, Nur Azurah ; Grover, Sonia ; McGregor, Duncan. / Plexiform schwannoma of the clitoris in a young girl : A case report. In: Journal of Reproductive Medicine. 2013 ; Vol. 58, No. 7-8. pp. 365-368.
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