Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Forty-nine methanol extracts of 37 species of Malaysian medicinal plants were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets, using 3H-PAF as a ligand. Among them, the extracts of six Zingiberaceae species (Alpinia galanga Swartz., Boesenbergia pandurata Roxb., Curcuma ochorrhiza Val., C. aeruginosa Roxb., Zingiber officinale Rosc. and Z. zerumbet Koenig.), two Cinnamomum species (C. altissimum Kosterm. and C. pubescens Kochummen.), Goniothalamus malayanus Hook. f. Momordica charantia Linn. and Piper aduncum L. are potential sources of new PAF antagonists, as they showed significant inhibitory effects with IC 50 values ranging from 1.2 to 18.4 μg ml-1.

Original languageEnglish
Pages (from-to)88-92
Number of pages5
JournalPhytomedicine
Volume12
Issue number1-2
DOIs
Publication statusPublished - 2005

Fingerprint

platelet-activating factor
Platelet Activating Factor
Medicinal Plants
Zingiberaceae
medicinal plants
antagonists
receptors
Curcuma aeruginosa
Goniothalamus
Zingiber zerumbet
Cinnamomum
Piper aduncum
Alpinia galanga
Alpinia
Momordica charantia
Piper
Curcuma
Ginger
Zingiber officinale
Hooks

Keywords

  • Antagonistic activity
  • Cinnamomum sp.
  • Malaysian medicinal plants
  • Platelet-activating factor (PAF)
  • Zingiberaceae sp.

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. / Jantan, Ibrahim; Rafi, I. A A; Jalil, Juriyati.

In: Phytomedicine, Vol. 12, No. 1-2, 2005, p. 88-92.

Research output: Contribution to journalArticle

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