Platelet-activating factor (PAF) antagonistic activity of a new biflavonoid from Garcinia nervosa var. pubescens king

Juriyati Jalil, Ibrahim Jantan, Azura Abdul Ghani, Shahnaz Murad

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The methanol extract of the leaves of Garcinia nervosa var. pubescens King, which showed strong inhibitory effects on platelet-activating factor (PAF) receptor binding, was subjected to bioassay-guided isolation to obtain a new biflavonoid, II-3,I-5, II-5,II-7,I-4',II-4'-hexahydroxy-(I-3,II-8)- flavonylflavanonol together with two known flavonoids, 6-methyl-4'- methoxyflavone and acacetin. The structures of the compounds were elucidated by spectroscopic methods. The compounds were evaluated for their ability to inhibit PAF receptor binding to rabbit platelets using 3H-PAF as a ligand. The biflavonoid and acacetin showed strong inhibition with IC 50 values of 28.0 and 20.4 μM, respectively. The results suggest that these compounds could be responsible for the strong PAF antagonistic activity of the plant.

Original languageEnglish
Pages (from-to)10893-10901
Number of pages9
JournalMolecules
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Biflavonoids
Garcinia
Platelet Activating Factor
platelets
Bioassay
Platelets
Flavonoids
Biological Assay
Methanol
Blood Platelets
Rabbits
Ligands
bioassay
rabbits
leaves
isolation
methyl alcohol
platelet activating factor receptor
acacetin
ligands

Keywords

  • Biflavonoid
  • Garcinia nervosa var. pubescens
  • Platelet-activating factor (PAF) antagonists
  • Platelets

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

Cite this

Platelet-activating factor (PAF) antagonistic activity of a new biflavonoid from Garcinia nervosa var. pubescens king. / Jalil, Juriyati; Jantan, Ibrahim; Ghani, Azura Abdul; Murad, Shahnaz.

In: Molecules, Vol. 17, No. 9, 09.2012, p. 10893-10901.

Research output: Contribution to journalArticle

Jalil, Juriyati ; Jantan, Ibrahim ; Ghani, Azura Abdul ; Murad, Shahnaz. / Platelet-activating factor (PAF) antagonistic activity of a new biflavonoid from Garcinia nervosa var. pubescens king. In: Molecules. 2012 ; Vol. 17, No. 9. pp. 10893-10901.
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