Platelet activating factor (PAF) antagonistic activities of compounds isolated from Guttiferae species

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Abstract

Nineteen compounds isolated from Calophyllum inophyllum, C. inophylloide, Garcinia opaca and G. bancana (Family: Guttiferae) were investigated for their platelet-activating factor (PAF) receptor binding inhibitory effects using rabbit platelets. Among them, five xanthones and a biflavonoid exhibited significant inhibitory effects. The compounds, 6-deoxyjacareubin, 2-(methylbut-2-enyl)-1,3,5-trihydoxyxanthone and 2-(3-methylbut-2-enyl)-1,3,5,6-tetrahydroxyxanthone isolated from C. inophyllum inhibited 3H-PAF binding to rabbit platelets with IC50 values of 4.8, 29.0 and 44.0 μM, respectively. The IC50 values of maclurax-anthone and 1,3,5-trihydroxy-6,6′ dimethylpyrano(2′,3′:6,7)-4-(1,1-dimethylprop-2-enyl)xanthone from G. opaca were 11.0 and 21.0 μM, respectively, and amentoflavone from C. inophylloide exhibited a IC50 value of 8.3 μM.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalPharmaceutical Biology
Volume39
Issue number4
DOIs
Publication statusPublished - 2001

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Clusiaceae
platelet-activating factor
Platelet Activating Factor
Calophyllum inophyllum
Platelets
Inhibitory Concentration 50
inhibitory concentration 50
Biflavonoids
Garcinia
Xanthones
Calophyllum
Blood Platelets
rabbits
Rabbits
xanthone
xanthones
receptors
1,3,5,6-tetrahydroxyxanthone
5,10-dihydroxy-2,2-dimethylpyrano(3,2-b)xanthen-6(2H)-one
amentoflavone

Keywords

  • Antagonistic activities
  • Calophyllum inophylloide
  • Calophyllum inophyllum
  • Garcinia bancana
  • Garcinia opaca
  • Guttiferae
  • Platelet-activating factor (PAF)

ASJC Scopus subject areas

  • Plant Science
  • Medical Laboratory Technology
  • Clinical Biochemistry
  • Pharmacology

Cite this

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title = "Platelet activating factor (PAF) antagonistic activities of compounds isolated from Guttiferae species",
abstract = "Nineteen compounds isolated from Calophyllum inophyllum, C. inophylloide, Garcinia opaca and G. bancana (Family: Guttiferae) were investigated for their platelet-activating factor (PAF) receptor binding inhibitory effects using rabbit platelets. Among them, five xanthones and a biflavonoid exhibited significant inhibitory effects. The compounds, 6-deoxyjacareubin, 2-(methylbut-2-enyl)-1,3,5-trihydoxyxanthone and 2-(3-methylbut-2-enyl)-1,3,5,6-tetrahydroxyxanthone isolated from C. inophyllum inhibited 3H-PAF binding to rabbit platelets with IC50 values of 4.8, 29.0 and 44.0 μM, respectively. The IC50 values of maclurax-anthone and 1,3,5-trihydroxy-6,6′ dimethylpyrano(2′,3′:6,7)-4-(1,1-dimethylprop-2-enyl)xanthone from G. opaca were 11.0 and 21.0 μM, respectively, and amentoflavone from C. inophylloide exhibited a IC50 value of 8.3 μM.",
keywords = "Antagonistic activities, Calophyllum inophylloide, Calophyllum inophyllum, Garcinia bancana, Garcinia opaca, Guttiferae, Platelet-activating factor (PAF)",
author = "Ibrahim Jantan and Juriyati Jalil and {Abd Warif}, {Nor Malia}",
year = "2001",
doi = "10.1076/phbi.39.4.243.5913",
language = "English",
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pages = "243--246",
journal = "Pharmaceutical Biology",
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T1 - Platelet activating factor (PAF) antagonistic activities of compounds isolated from Guttiferae species

AU - Jantan, Ibrahim

AU - Jalil, Juriyati

AU - Abd Warif, Nor Malia

PY - 2001

Y1 - 2001

N2 - Nineteen compounds isolated from Calophyllum inophyllum, C. inophylloide, Garcinia opaca and G. bancana (Family: Guttiferae) were investigated for their platelet-activating factor (PAF) receptor binding inhibitory effects using rabbit platelets. Among them, five xanthones and a biflavonoid exhibited significant inhibitory effects. The compounds, 6-deoxyjacareubin, 2-(methylbut-2-enyl)-1,3,5-trihydoxyxanthone and 2-(3-methylbut-2-enyl)-1,3,5,6-tetrahydroxyxanthone isolated from C. inophyllum inhibited 3H-PAF binding to rabbit platelets with IC50 values of 4.8, 29.0 and 44.0 μM, respectively. The IC50 values of maclurax-anthone and 1,3,5-trihydroxy-6,6′ dimethylpyrano(2′,3′:6,7)-4-(1,1-dimethylprop-2-enyl)xanthone from G. opaca were 11.0 and 21.0 μM, respectively, and amentoflavone from C. inophylloide exhibited a IC50 value of 8.3 μM.

AB - Nineteen compounds isolated from Calophyllum inophyllum, C. inophylloide, Garcinia opaca and G. bancana (Family: Guttiferae) were investigated for their platelet-activating factor (PAF) receptor binding inhibitory effects using rabbit platelets. Among them, five xanthones and a biflavonoid exhibited significant inhibitory effects. The compounds, 6-deoxyjacareubin, 2-(methylbut-2-enyl)-1,3,5-trihydoxyxanthone and 2-(3-methylbut-2-enyl)-1,3,5,6-tetrahydroxyxanthone isolated from C. inophyllum inhibited 3H-PAF binding to rabbit platelets with IC50 values of 4.8, 29.0 and 44.0 μM, respectively. The IC50 values of maclurax-anthone and 1,3,5-trihydroxy-6,6′ dimethylpyrano(2′,3′:6,7)-4-(1,1-dimethylprop-2-enyl)xanthone from G. opaca were 11.0 and 21.0 μM, respectively, and amentoflavone from C. inophylloide exhibited a IC50 value of 8.3 μM.

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