Plasmodium vivax and Plasmodium falciparum at the crossroads of exchange among Islands in Vanuatu: Implications for malaria elimination strategies

Chim W. Chan, Naoko Sakihama, Shin Ichiro Tachibana, Zulkarnain Md Idris, J. Koji Lum, Kazuyuki Tanabe, Akira Kaneko

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Understanding the transmission and movement of Plasmodium parasites is crucial for malaria elimination and prevention of resurgence. Located at the limit of malaria transmission in the Pacific, Vanuatu is an ideal candidate for elimination programs due to low endemicity and the isolated nature of its island setting. We analyzed the variation in the merozoite surface protein 1 (msp1) and the circumsporozoite protein (csp) of P. falciparum and P. vivax populations to examine the patterns of gene flow and population structures among seven sites on five islands in Vanuatu. Genetic diversity was in general higher in P. vivax than P. falciparum from the same site. In P. vivax, high genetic diversity was likely maintained by greater extent of gene flow among sites and among islands. Consistent with the different patterns of gene flow, the proportion of genetic variance found among islands was substantially higher in P. falciparum (28.81-31.23%) than in P. vivax (-0.53-3.99%). Our data suggest that the current island-by-island malaria elimination strategy in Vanuatu, while adequate for P. falciparum elimination, might need to be complemented with more centrally integrated measures to control P. vivax movement across islands.

Original languageEnglish
Article numbere0119475
JournalPLoS One
Volume10
Issue number3
DOIs
Publication statusPublished - 20 Mar 2015
Externally publishedYes

Fingerprint

Vanuatu
Plasmodium vivax
Plasmodium falciparum
Islands
malaria
Malaria
Genes
Gene Flow
Merozoite Surface Protein 1
gene flow
genetic variation
merozoites
Plasmodium
surface proteins
genetic variance
Proteins
Population
population structure
Parasites
indigenous species

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Plasmodium vivax and Plasmodium falciparum at the crossroads of exchange among Islands in Vanuatu : Implications for malaria elimination strategies. / Chan, Chim W.; Sakihama, Naoko; Tachibana, Shin Ichiro; Md Idris, Zulkarnain; Lum, J. Koji; Tanabe, Kazuyuki; Kaneko, Akira.

In: PLoS One, Vol. 10, No. 3, e0119475, 20.03.2015.

Research output: Contribution to journalArticle

Chan, Chim W. ; Sakihama, Naoko ; Tachibana, Shin Ichiro ; Md Idris, Zulkarnain ; Lum, J. Koji ; Tanabe, Kazuyuki ; Kaneko, Akira. / Plasmodium vivax and Plasmodium falciparum at the crossroads of exchange among Islands in Vanuatu : Implications for malaria elimination strategies. In: PLoS One. 2015 ; Vol. 10, No. 3.
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