Plasma vitamin C and tocotrienols changes in response to dietary supplementation among young male adults

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Abstract

Background and Aims. Intake of the antioxidant vitamins C and E lowers the oxidative stress. The study aimed to determine plasma concentrations of vitamin C and tocotrienols after supplementation of both vitamins in young male adults. Materials and Methods. A total of 64 police recruits were randomly assigned to one of these groups: (a) 500 mg vitamin C (Vitamin C), (b) 200 mg Tocovid™(Tocotrienol), (c) combination of 500 mg vitamin C and 200 mg Tocovid™ (Combination) or (d) placebo (Placebo) for eight-weeks of supplementation followed by six-week washout period. Results. In Combination group, mean plasma vitamin C concentration significantly increased from baseline 2.86 ± 1.19 mg/L to 10.37 ± 1.29 mg/L and 15.63 ± 1.27 mg/L after four- and eight-week supplementation, respectively. The corresponding figures for α-, δ- and γ-tocotrienols were 9.9 ± 2.5 ng/ml to 104.1 ± 19.8 ng/ml and 112.8 ± 38.0 ng/ml; 2.5 ± 0.9 ng/ml to 29.9 ± 7.0 ng/ml and 17.9 ± 4.7 ng/ml; 19.2 ± 3.1 ng/ml to 75.2 ± 24.1 ng/ml and 161.7 ± 49.9 ng/ml, respectively. In Vitamin C group, plasma vitamin C concentrations were significantly increased. Conversely, concentration of plasma vitamin C in Tocotrienol group increased from baseline of 2.72 ± 0.20 mg/L to 6.80 ± 0.63 mg/L and 8.9 ± 0.77 mg/L respectively. Plasma concentrations of α-, δ- and γ-tocotrienols in this group were significantly elevated. After 6-week washout period, all the elevated concentrations returned to basal levels. Conclusion. The study showed a good bioavailability of these vitamins and increment due to supplementation.

Original languageEnglish
Pages (from-to)121-124
Number of pages4
JournalClinica Terapeutica
Volume161
Issue number2
Publication statusPublished - Mar 2010

Fingerprint

Tocotrienols
Dietary Supplements
Ascorbic Acid
Young Adult
Vitamins
Placebos
Police
Vitamin E
Biological Availability
Oxidative Stress
Antioxidants

Keywords

  • Antioxidant
  • Supplementation
  • Tocotrienols
  • Vitamin C
  • Young adults

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{126d98164bba43f5a3a5d001bfa2dfcb,
title = "Plasma vitamin C and tocotrienols changes in response to dietary supplementation among young male adults",
abstract = "Background and Aims. Intake of the antioxidant vitamins C and E lowers the oxidative stress. The study aimed to determine plasma concentrations of vitamin C and tocotrienols after supplementation of both vitamins in young male adults. Materials and Methods. A total of 64 police recruits were randomly assigned to one of these groups: (a) 500 mg vitamin C (Vitamin C), (b) 200 mg Tocovid™(Tocotrienol), (c) combination of 500 mg vitamin C and 200 mg Tocovid™ (Combination) or (d) placebo (Placebo) for eight-weeks of supplementation followed by six-week washout period. Results. In Combination group, mean plasma vitamin C concentration significantly increased from baseline 2.86 ± 1.19 mg/L to 10.37 ± 1.29 mg/L and 15.63 ± 1.27 mg/L after four- and eight-week supplementation, respectively. The corresponding figures for α-, δ- and γ-tocotrienols were 9.9 ± 2.5 ng/ml to 104.1 ± 19.8 ng/ml and 112.8 ± 38.0 ng/ml; 2.5 ± 0.9 ng/ml to 29.9 ± 7.0 ng/ml and 17.9 ± 4.7 ng/ml; 19.2 ± 3.1 ng/ml to 75.2 ± 24.1 ng/ml and 161.7 ± 49.9 ng/ml, respectively. In Vitamin C group, plasma vitamin C concentrations were significantly increased. Conversely, concentration of plasma vitamin C in Tocotrienol group increased from baseline of 2.72 ± 0.20 mg/L to 6.80 ± 0.63 mg/L and 8.9 ± 0.77 mg/L respectively. Plasma concentrations of α-, δ- and γ-tocotrienols in this group were significantly elevated. After 6-week washout period, all the elevated concentrations returned to basal levels. Conclusion. The study showed a good bioavailability of these vitamins and increment due to supplementation.",
keywords = "Antioxidant, Supplementation, Tocotrienols, Vitamin C, Young adults",
author = "{Abdul Manaf}, Zahara and Lee, {C. C.} and Ibrahim, {Siti Fatimah} and Poh, {Bee Koon} and Khairul Osman and Srijit Das and Jamaludin Mohamed",
year = "2010",
month = "3",
language = "English",
volume = "161",
pages = "121--124",
journal = "Clinica Terapeutica",
issn = "0009-9074",
publisher = "Societa Editrice Universo",
number = "2",

}

TY - JOUR

T1 - Plasma vitamin C and tocotrienols changes in response to dietary supplementation among young male adults

AU - Abdul Manaf, Zahara

AU - Lee, C. C.

AU - Ibrahim, Siti Fatimah

AU - Poh, Bee Koon

AU - Osman, Khairul

AU - Das, Srijit

AU - Mohamed, Jamaludin

PY - 2010/3

Y1 - 2010/3

N2 - Background and Aims. Intake of the antioxidant vitamins C and E lowers the oxidative stress. The study aimed to determine plasma concentrations of vitamin C and tocotrienols after supplementation of both vitamins in young male adults. Materials and Methods. A total of 64 police recruits were randomly assigned to one of these groups: (a) 500 mg vitamin C (Vitamin C), (b) 200 mg Tocovid™(Tocotrienol), (c) combination of 500 mg vitamin C and 200 mg Tocovid™ (Combination) or (d) placebo (Placebo) for eight-weeks of supplementation followed by six-week washout period. Results. In Combination group, mean plasma vitamin C concentration significantly increased from baseline 2.86 ± 1.19 mg/L to 10.37 ± 1.29 mg/L and 15.63 ± 1.27 mg/L after four- and eight-week supplementation, respectively. The corresponding figures for α-, δ- and γ-tocotrienols were 9.9 ± 2.5 ng/ml to 104.1 ± 19.8 ng/ml and 112.8 ± 38.0 ng/ml; 2.5 ± 0.9 ng/ml to 29.9 ± 7.0 ng/ml and 17.9 ± 4.7 ng/ml; 19.2 ± 3.1 ng/ml to 75.2 ± 24.1 ng/ml and 161.7 ± 49.9 ng/ml, respectively. In Vitamin C group, plasma vitamin C concentrations were significantly increased. Conversely, concentration of plasma vitamin C in Tocotrienol group increased from baseline of 2.72 ± 0.20 mg/L to 6.80 ± 0.63 mg/L and 8.9 ± 0.77 mg/L respectively. Plasma concentrations of α-, δ- and γ-tocotrienols in this group were significantly elevated. After 6-week washout period, all the elevated concentrations returned to basal levels. Conclusion. The study showed a good bioavailability of these vitamins and increment due to supplementation.

AB - Background and Aims. Intake of the antioxidant vitamins C and E lowers the oxidative stress. The study aimed to determine plasma concentrations of vitamin C and tocotrienols after supplementation of both vitamins in young male adults. Materials and Methods. A total of 64 police recruits were randomly assigned to one of these groups: (a) 500 mg vitamin C (Vitamin C), (b) 200 mg Tocovid™(Tocotrienol), (c) combination of 500 mg vitamin C and 200 mg Tocovid™ (Combination) or (d) placebo (Placebo) for eight-weeks of supplementation followed by six-week washout period. Results. In Combination group, mean plasma vitamin C concentration significantly increased from baseline 2.86 ± 1.19 mg/L to 10.37 ± 1.29 mg/L and 15.63 ± 1.27 mg/L after four- and eight-week supplementation, respectively. The corresponding figures for α-, δ- and γ-tocotrienols were 9.9 ± 2.5 ng/ml to 104.1 ± 19.8 ng/ml and 112.8 ± 38.0 ng/ml; 2.5 ± 0.9 ng/ml to 29.9 ± 7.0 ng/ml and 17.9 ± 4.7 ng/ml; 19.2 ± 3.1 ng/ml to 75.2 ± 24.1 ng/ml and 161.7 ± 49.9 ng/ml, respectively. In Vitamin C group, plasma vitamin C concentrations were significantly increased. Conversely, concentration of plasma vitamin C in Tocotrienol group increased from baseline of 2.72 ± 0.20 mg/L to 6.80 ± 0.63 mg/L and 8.9 ± 0.77 mg/L respectively. Plasma concentrations of α-, δ- and γ-tocotrienols in this group were significantly elevated. After 6-week washout period, all the elevated concentrations returned to basal levels. Conclusion. The study showed a good bioavailability of these vitamins and increment due to supplementation.

KW - Antioxidant

KW - Supplementation

KW - Tocotrienols

KW - Vitamin C

KW - Young adults

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