Plasma Renin and Aldosterone in Thyroid Diseases

B. J. Asmah, W. M. Wan Nazaimoon, Nor Azmi Kamaruddin, T. T. Tan, B. A K Khalid

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The effect of thyroid hormones on the renin-angiotensin-aldosterone system has not been fully resolved. Highly specific immunoassays for measurement of renin, aldosterone, free T4 (fT4), free T3 (fT3) and ultrasensitive TSH enables a direct and more accurate measurement of these hormones. We investigated the relationship between plasma renin, aldosterone and thyroid hormones in the basal state and after intravenous frusemide. This is a cross-sectional study involving 37 patients with thyrotoxicosis, 42 rendered euthyroid with normal fT4, fT3 and TSH levels, 17 with euthyroid levels, 17 with euthyroid levels of fT4 and fT3 but suppressed TSH, and 11 with hypothyroidism. Basal plasma renin was significant higher in thyrotoxicosis (63.4±9.8 μU/ml, mean±SEM) compared to euthyroid (32.7±4.4 μU/ml). Basal plasma renin for euthyroid with suppressed TSH (41.0±7.4 μU/ml) was significantly higher than hypothyroid (p = 0.02). Basal plasma aldosterones were not significantly different except for suppressed TSH (157.7±13 pg/ml), which was higher than normal (109.9±10.4 pg/ml: p = 0.04). Following frusemide, plasma renin and aldosterone were significantly increased in all groups. Plasma renin was highly correlated to fT3 (r = 0.405, p < 0.001), total T3 (r = 0.359, p < 0.001), ft4 (r = 0.331, p < 0.001) and TSH (r = 0.300, p < 0.001) in the basal state, but less to total T4 (r = 0.248, p < 0.01). Plasma renin correlated poorly to serum aldosterone (r = 0.212, p < 0.03). This study clearly showed that regulation of renin was mainly influenced by fT3, and that aldosterone response to frusemide was blunted in thyrotoxicosis despite normal electrolytes.

Original languageEnglish
Pages (from-to)580-583
Number of pages4
JournalHormone and Metabolic Research
Volume29
Issue number11
Publication statusPublished - 1997

Fingerprint

Thyroid Diseases
Aldosterone
Renin
Plasmas
Thyrotoxicosis
Furosemide
Thyroid Hormones
Renin-Angiotensin System
Hypothyroidism
Immunoassay
Angiotensins
Electrolytes
Cross-Sectional Studies
Hormones
Serum

Keywords

  • Aldosterone
  • Renin
  • Thyroid disease

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Asmah, B. J., Wan Nazaimoon, W. M., Kamaruddin, N. A., Tan, T. T., & Khalid, B. A. K. (1997). Plasma Renin and Aldosterone in Thyroid Diseases. Hormone and Metabolic Research, 29(11), 580-583.

Plasma Renin and Aldosterone in Thyroid Diseases. / Asmah, B. J.; Wan Nazaimoon, W. M.; Kamaruddin, Nor Azmi; Tan, T. T.; Khalid, B. A K.

In: Hormone and Metabolic Research, Vol. 29, No. 11, 1997, p. 580-583.

Research output: Contribution to journalArticle

Asmah, BJ, Wan Nazaimoon, WM, Kamaruddin, NA, Tan, TT & Khalid, BAK 1997, 'Plasma Renin and Aldosterone in Thyroid Diseases', Hormone and Metabolic Research, vol. 29, no. 11, pp. 580-583.
Asmah BJ, Wan Nazaimoon WM, Kamaruddin NA, Tan TT, Khalid BAK. Plasma Renin and Aldosterone in Thyroid Diseases. Hormone and Metabolic Research. 1997;29(11):580-583.
Asmah, B. J. ; Wan Nazaimoon, W. M. ; Kamaruddin, Nor Azmi ; Tan, T. T. ; Khalid, B. A K. / Plasma Renin and Aldosterone in Thyroid Diseases. In: Hormone and Metabolic Research. 1997 ; Vol. 29, No. 11. pp. 580-583.
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