Plasma methods for the generation of chemically reactive surfaces for biomolecule immobilization and cell colonization - A review

Kim Shyong Siow, Leanne Britcher, Sunil Kumar, Hans J. Griesser

Research output: Contribution to journalArticle

676 Citations (Scopus)

Abstract

This review surveys methods for the fabrication, by plasma surface treatments or plasma polymerization, of polymeric surfaces and thin plasma polymer coatings that contain reactive chemical groups useful for the subsequent covalent immobilization, by solution chemical reactions or vapor phase grafting, of molecules or polymers that can exert bio-specific interfacial responses. Surfaces containing amine, carboxy, hydroxy, and aldehyde groups are the subject of this review. Aminated surfaces have been fabricated using various plasma vapors or mixtures and have found wide use for bio-interface applications. However, in many cases the amine surfaces have a rather limited shelf life, with post-plasma oxidation reactions and surface adaptation leading to the disappearance of amine groups from the surface. Aging is a widespread phenomenon that often has not been recognized, particularly in some of the earlier studies on the use of plasma-fabricated surfaces for bio-interfacial applications, and can markedly alter the surface chemistry. Plasma-fabricated surfaces that contain carboxy groups have also been well documented. Fewer reports exist on hydroxy and aldehyde surfaces prepared by plasma methods. Hydroxy surfaces can be prepared by water plasma treatment or the plasma polymerization of alkyl alcohol vapors. Water plasma treatment on many polymer substrates suffers from aging, with surface adaptation leading to the movement of surface modification effects into the polymer. Both hydroxy and aldehyde surfaces have been used for the covalent immobilization of biologically active molecules. Aging effects are less well documented than for amine surfaces. This review also surveys studies using such surfaces for cell colonization assays. Generally, these surface chemistries show good ability to support cell colonization, though the effectiveness seems to depend on the process vapor and the plasma conditions. Carboxylate co-polymer surfaces have shown excellent abilllity to support the colonization of some human cell lines of clinical interest. Immobilization of proteins onto plasma-carboxylated surfaces is also well established.

Original languageEnglish
Pages (from-to)392-418
Number of pages27
JournalPlasma Processes and Polymers
Volume3
Issue number6-7
DOIs
Publication statusPublished - 15 Aug 2006
Externally publishedYes

Fingerprint

Biomolecules
immobilization
Plasmas
cells
Polymers
Amines
Aldehydes
Vapors
amines
Plasma polymerization
aldehydes
Aging of materials
polymers
Surface chemistry
vapors
Surface treatment
polymerization
Molecules
chemistry
Water

Keywords

  • Aldehyde
  • Amine
  • Bio-interfaces
  • Biomaterials
  • Carboxyl groups
  • Cell colonization
  • Derivatization
  • Hydroxy groups
  • Immobilization
  • Plasma polymerization
  • Plasma treatment

ASJC Scopus subject areas

  • Polymers and Plastics
  • Physics and Astronomy (miscellaneous)

Cite this

Plasma methods for the generation of chemically reactive surfaces for biomolecule immobilization and cell colonization - A review. / Siow, Kim Shyong; Britcher, Leanne; Kumar, Sunil; Griesser, Hans J.

In: Plasma Processes and Polymers, Vol. 3, No. 6-7, 15.08.2006, p. 392-418.

Research output: Contribution to journalArticle

@article{e80db88e555c495faacf1ab0a6aef2f2,
title = "Plasma methods for the generation of chemically reactive surfaces for biomolecule immobilization and cell colonization - A review",
abstract = "This review surveys methods for the fabrication, by plasma surface treatments or plasma polymerization, of polymeric surfaces and thin plasma polymer coatings that contain reactive chemical groups useful for the subsequent covalent immobilization, by solution chemical reactions or vapor phase grafting, of molecules or polymers that can exert bio-specific interfacial responses. Surfaces containing amine, carboxy, hydroxy, and aldehyde groups are the subject of this review. Aminated surfaces have been fabricated using various plasma vapors or mixtures and have found wide use for bio-interface applications. However, in many cases the amine surfaces have a rather limited shelf life, with post-plasma oxidation reactions and surface adaptation leading to the disappearance of amine groups from the surface. Aging is a widespread phenomenon that often has not been recognized, particularly in some of the earlier studies on the use of plasma-fabricated surfaces for bio-interfacial applications, and can markedly alter the surface chemistry. Plasma-fabricated surfaces that contain carboxy groups have also been well documented. Fewer reports exist on hydroxy and aldehyde surfaces prepared by plasma methods. Hydroxy surfaces can be prepared by water plasma treatment or the plasma polymerization of alkyl alcohol vapors. Water plasma treatment on many polymer substrates suffers from aging, with surface adaptation leading to the movement of surface modification effects into the polymer. Both hydroxy and aldehyde surfaces have been used for the covalent immobilization of biologically active molecules. Aging effects are less well documented than for amine surfaces. This review also surveys studies using such surfaces for cell colonization assays. Generally, these surface chemistries show good ability to support cell colonization, though the effectiveness seems to depend on the process vapor and the plasma conditions. Carboxylate co-polymer surfaces have shown excellent abilllity to support the colonization of some human cell lines of clinical interest. Immobilization of proteins onto plasma-carboxylated surfaces is also well established.",
keywords = "Aldehyde, Amine, Bio-interfaces, Biomaterials, Carboxyl groups, Cell colonization, Derivatization, Hydroxy groups, Immobilization, Plasma polymerization, Plasma treatment",
author = "Siow, {Kim Shyong} and Leanne Britcher and Sunil Kumar and Griesser, {Hans J.}",
year = "2006",
month = "8",
day = "15",
doi = "10.1002/ppap.200600021",
language = "English",
volume = "3",
pages = "392--418",
journal = "Plasma Processes and Polymers",
issn = "1612-8850",
publisher = "Wiley-VCH Verlag",
number = "6-7",

}

TY - JOUR

T1 - Plasma methods for the generation of chemically reactive surfaces for biomolecule immobilization and cell colonization - A review

AU - Siow, Kim Shyong

AU - Britcher, Leanne

AU - Kumar, Sunil

AU - Griesser, Hans J.

PY - 2006/8/15

Y1 - 2006/8/15

N2 - This review surveys methods for the fabrication, by plasma surface treatments or plasma polymerization, of polymeric surfaces and thin plasma polymer coatings that contain reactive chemical groups useful for the subsequent covalent immobilization, by solution chemical reactions or vapor phase grafting, of molecules or polymers that can exert bio-specific interfacial responses. Surfaces containing amine, carboxy, hydroxy, and aldehyde groups are the subject of this review. Aminated surfaces have been fabricated using various plasma vapors or mixtures and have found wide use for bio-interface applications. However, in many cases the amine surfaces have a rather limited shelf life, with post-plasma oxidation reactions and surface adaptation leading to the disappearance of amine groups from the surface. Aging is a widespread phenomenon that often has not been recognized, particularly in some of the earlier studies on the use of plasma-fabricated surfaces for bio-interfacial applications, and can markedly alter the surface chemistry. Plasma-fabricated surfaces that contain carboxy groups have also been well documented. Fewer reports exist on hydroxy and aldehyde surfaces prepared by plasma methods. Hydroxy surfaces can be prepared by water plasma treatment or the plasma polymerization of alkyl alcohol vapors. Water plasma treatment on many polymer substrates suffers from aging, with surface adaptation leading to the movement of surface modification effects into the polymer. Both hydroxy and aldehyde surfaces have been used for the covalent immobilization of biologically active molecules. Aging effects are less well documented than for amine surfaces. This review also surveys studies using such surfaces for cell colonization assays. Generally, these surface chemistries show good ability to support cell colonization, though the effectiveness seems to depend on the process vapor and the plasma conditions. Carboxylate co-polymer surfaces have shown excellent abilllity to support the colonization of some human cell lines of clinical interest. Immobilization of proteins onto plasma-carboxylated surfaces is also well established.

AB - This review surveys methods for the fabrication, by plasma surface treatments or plasma polymerization, of polymeric surfaces and thin plasma polymer coatings that contain reactive chemical groups useful for the subsequent covalent immobilization, by solution chemical reactions or vapor phase grafting, of molecules or polymers that can exert bio-specific interfacial responses. Surfaces containing amine, carboxy, hydroxy, and aldehyde groups are the subject of this review. Aminated surfaces have been fabricated using various plasma vapors or mixtures and have found wide use for bio-interface applications. However, in many cases the amine surfaces have a rather limited shelf life, with post-plasma oxidation reactions and surface adaptation leading to the disappearance of amine groups from the surface. Aging is a widespread phenomenon that often has not been recognized, particularly in some of the earlier studies on the use of plasma-fabricated surfaces for bio-interfacial applications, and can markedly alter the surface chemistry. Plasma-fabricated surfaces that contain carboxy groups have also been well documented. Fewer reports exist on hydroxy and aldehyde surfaces prepared by plasma methods. Hydroxy surfaces can be prepared by water plasma treatment or the plasma polymerization of alkyl alcohol vapors. Water plasma treatment on many polymer substrates suffers from aging, with surface adaptation leading to the movement of surface modification effects into the polymer. Both hydroxy and aldehyde surfaces have been used for the covalent immobilization of biologically active molecules. Aging effects are less well documented than for amine surfaces. This review also surveys studies using such surfaces for cell colonization assays. Generally, these surface chemistries show good ability to support cell colonization, though the effectiveness seems to depend on the process vapor and the plasma conditions. Carboxylate co-polymer surfaces have shown excellent abilllity to support the colonization of some human cell lines of clinical interest. Immobilization of proteins onto plasma-carboxylated surfaces is also well established.

KW - Aldehyde

KW - Amine

KW - Bio-interfaces

KW - Biomaterials

KW - Carboxyl groups

KW - Cell colonization

KW - Derivatization

KW - Hydroxy groups

KW - Immobilization

KW - Plasma polymerization

KW - Plasma treatment

UR - http://www.scopus.com/inward/record.url?scp=33748419487&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748419487&partnerID=8YFLogxK

U2 - 10.1002/ppap.200600021

DO - 10.1002/ppap.200600021

M3 - Article

VL - 3

SP - 392

EP - 418

JO - Plasma Processes and Polymers

JF - Plasma Processes and Polymers

SN - 1612-8850

IS - 6-7

ER -