Plasma antioxidants and lipid peroxidation products in Duchenne muscular dystrophy

M. Ian S Hunter, Jamaludin Mohamed

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Lipid peroxidation (LPX) products in plasma were elevated in Duchenne muscular dystrophy (DMD) patients (n = 9) compared with an age- and sex-matched group of controls (n = 10). Trichloroacetic acid-precipitable thiobarbituric acid-reactive substances (TBARS) were increased by 35% (p <0.01), conjugated dienes by 77% (p < 0.02) and fluorescent pigments (FP) by 70% (p < 0.001). Plasma alpha-tocopherol was significantly decreased, by 50%, in DMD compared with healthy subjects (p < 0.002). In conjunction with the finding of others of a deficiency in DMD of the plasma lipoproteins which normally transport vitamin E to the tissues, this may contribute to the increased LPX seen in the disease especially if muscle damage also liberates free Fe2+. The major circulating antioxidant protein, caeruloplasmin (CP), was significantly increased (p < 0.001) by 25-30% in DMD patients compared with both adult and young male controls. In DMD patients only, this increase is correlated with the concentration of TBARS and FP suggesting that increased LPX may be a trigger for CP synthesis.

Original languageEnglish
Pages (from-to)123-131
Number of pages9
JournalClinica Chimica Acta
Volume155
Issue number2
DOIs
Publication statusPublished - 16 Mar 1986
Externally publishedYes

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Duchenne Muscular Dystrophy
Lipid Peroxidation
Ceruloplasmin
Thiobarbituric Acid Reactive Substances
Antioxidants
Lipids
Plasmas
Pigments
Trichloroacetic Acid
alpha-Tocopherol
Vitamin E
Lipoproteins
Muscle
Tissue
Young Adult
Healthy Volunteers
Research Design
Proteins
Muscles

Keywords

  • Antioxidants
  • Duchenne muscular dystrophy
  • Fluorescent pigments
  • Lipid peroxidation
  • Plasma
  • Vitamin E

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

Plasma antioxidants and lipid peroxidation products in Duchenne muscular dystrophy. / Hunter, M. Ian S; Mohamed, Jamaludin.

In: Clinica Chimica Acta, Vol. 155, No. 2, 16.03.1986, p. 123-131.

Research output: Contribution to journalArticle

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