Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Farida Hussan, Rina Haryani Osman Basah, Mohd Rafizul Mohd Yusof, Nur Aqilah Kamaruddin, Faizah Othman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To determine the effect of Plantago major (P.major) extract on the liver injury following acetaminophen (APAP) toxicity. Methods: The male Sprague Dawley rats (n=38) were randomly divided into normal control (n=6) and experiment (n=32) groups. The latter was subdivided into four groups and induced with APAP (1. 000mg/kg) per oral, followed by P.major extract and N-acetylcysteine orally to the respective groups for six days. Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed significant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The findings in the extract treated groups were comparable to the group treated with N-acetylcysteine. Conclusions: In conclusion, P.major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury.

Original languageEnglish
JournalAsian Pacific Journal of Tropical Biomedicine
DOIs
Publication statusAccepted/In press - 23 Mar 2015

Fingerprint

Plantago
Acetaminophen
Toxicity
Antioxidants
Liver
Acetylcysteine
Malondialdehyde
Superoxide Dismutase
Glutathione
Tissue
Liver Extracts
Plant Extracts
Wounds and Injuries
Bilirubin
Sprague Dawley Rats
Deterioration
Rats
Blood Proteins
Cytoplasm
Agglomeration

Keywords

  • Acetaminophen
  • Antioxidants
  • Liver injury
  • Oxidative stress
  • Plantago major

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

Cite this

Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity. / Hussan, Farida; Osman Basah, Rina Haryani; Mohd Yusof, Mohd Rafizul; Kamaruddin, Nur Aqilah; Othman, Faizah.

In: Asian Pacific Journal of Tropical Biomedicine, 23.03.2015.

Research output: Contribution to journalArticle

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abstract = "Objective: To determine the effect of Plantago major (P.major) extract on the liver injury following acetaminophen (APAP) toxicity. Methods: The male Sprague Dawley rats (n=38) were randomly divided into normal control (n=6) and experiment (n=32) groups. The latter was subdivided into four groups and induced with APAP (1. 000mg/kg) per oral, followed by P.major extract and N-acetylcysteine orally to the respective groups for six days. Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed significant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The findings in the extract treated groups were comparable to the group treated with N-acetylcysteine. Conclusions: In conclusion, P.major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury.",
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AU - Osman Basah, Rina Haryani

AU - Mohd Yusof, Mohd Rafizul

AU - Kamaruddin, Nur Aqilah

AU - Othman, Faizah

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N2 - Objective: To determine the effect of Plantago major (P.major) extract on the liver injury following acetaminophen (APAP) toxicity. Methods: The male Sprague Dawley rats (n=38) were randomly divided into normal control (n=6) and experiment (n=32) groups. The latter was subdivided into four groups and induced with APAP (1. 000mg/kg) per oral, followed by P.major extract and N-acetylcysteine orally to the respective groups for six days. Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed significant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The findings in the extract treated groups were comparable to the group treated with N-acetylcysteine. Conclusions: In conclusion, P.major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury.

AB - Objective: To determine the effect of Plantago major (P.major) extract on the liver injury following acetaminophen (APAP) toxicity. Methods: The male Sprague Dawley rats (n=38) were randomly divided into normal control (n=6) and experiment (n=32) groups. The latter was subdivided into four groups and induced with APAP (1. 000mg/kg) per oral, followed by P.major extract and N-acetylcysteine orally to the respective groups for six days. Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed significant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The findings in the extract treated groups were comparable to the group treated with N-acetylcysteine. Conclusions: In conclusion, P.major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury.

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