Plant-derived immunomodulators

An insight on their preclinical evaluation and clinical trials

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The phagocyte-microbe interactions in the immune system is a defense mechanism but when excessively or inappropriately deployed can harm host tissues and participate in the development of different non-immune and immune chronic inflammatory diseases such as autoimmune problems, allergies, some rheumatoid disorders, cancers and others. Immunodrugs include organic synthetics, biological agents such as cytokines and antibodies acting on single targets or pathways have been used to treat immune-related diseases but with limited success. Most of immunostimulants and immunosuppressants in clinical use are the cytotoxic drugs which possess serious side effects. There is a growing interest to use herbal medicines as multi-component agents to modulate the complex immune system in the prevention of infections rather than treating the immune-related diseases. Many therapeutic effects of plant extracts have been suggested to be due to their wide array of immunomodulatory effects and influence on the immune system of the human body. Phytochemicals such as flavonoids, polysaccharides, lactones, alkaloids, diterpenoids and glycosides, present in several plants, have been reported to be responsible for the plants immunomodulating properties. Thus the search for natural products of plant origin as new leads for development of potent and safe immunosuppressant and immunostimulant agents is gaining much major research interest. The present review will give an overview of widely investigated plant-derived compounds (curcumin, resveratrol, epigallocatechol- 3-gallate, quercetin, colchicine, capsaicin, andrographolide, and genistein) which have exhibited potent effects on cellular and humoral immune functions in pre-clinical investigations and will highlight their clinical potential.

Original languageEnglish
Article numberA655
JournalFrontiers in Plant Science
Volume6
Issue numberAUG
DOIs
Publication statusPublished - 25 Aug 2015

Fingerprint

immunomodulators
immune system
immunosuppressive agents
immunostimulants
clinical trials
diterpenoid alkaloids
capsaicin
curcumin
plant products
epigallocatechin
phagocytes
herbal medicines
resveratrol
genistein
colchicine
lactones
defense mechanisms
plant extracts
hypersensitivity
quercetin

Keywords

  • Capsaicin
  • Colchicine
  • Curcumin
  • Epigallocatechol-3-gallate
  • Immunomodulation
  • Quercetin
  • Resveratrol

ASJC Scopus subject areas

  • Plant Science

Cite this

Plant-derived immunomodulators : An insight on their preclinical evaluation and clinical trials. / Jantan, Ibrahim; Ahmad, Waqas; Syed Nasir Abbas, Bukhari.

In: Frontiers in Plant Science, Vol. 6, No. AUG, A655, 25.08.2015.

Research output: Contribution to journalArticle

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