Pituitary thyroid resistance syndrome

Norlela Sukor, K. Nor Azml, B. A K Khalid

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Thyroid hormone resistance (RTH) is a rare autosomal dominant disorder, characterized clinically by goiter and biochemically by elevated circulating free thyroid hormone levels in the presence of measurable serum thyroid-stimulating hormone (TSH) concentrations. About 85% of patients with RTH harbor mutations in thyroid hormone receptor [beta] (TR[beta]). Even rarer is pituitary thyroid resistance syndrome. We report a case of a 35-year-old man who presented with hypermetabolic symptoms with elevated levels of thyroid hormones, associated with non-suppressed thyrotropin (TSH). When treated with anti-thyroid drugs, his thyroid hormone levels normalized and TSH increased, suggesting thyroid resistance at the pituitary level.

Original languageEnglish
Pages (from-to)642-643
Number of pages2
JournalMedical Journal of Malaysia
Volume60
Issue number5
Publication statusPublished - 2005

Fingerprint

Thyrotropin
Thyroid Gland
Thyroid Hormones
Thyroid Hormone Resistance Syndrome
Thyroid Hormone Receptors
Goiter
Mutation
Serum
Pharmaceutical Preparations

Keywords

  • Hyperthyroidism
  • Pituitary thyroid resistance syndrome
  • Thyroid hormone resistance

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sukor, N., Azml, K. N., & Khalid, B. A. K. (2005). Pituitary thyroid resistance syndrome. Medical Journal of Malaysia, 60(5), 642-643.

Pituitary thyroid resistance syndrome. / Sukor, Norlela; Azml, K. Nor; Khalid, B. A K.

In: Medical Journal of Malaysia, Vol. 60, No. 5, 2005, p. 642-643.

Research output: Contribution to journalArticle

Sukor, N, Azml, KN & Khalid, BAK 2005, 'Pituitary thyroid resistance syndrome', Medical Journal of Malaysia, vol. 60, no. 5, pp. 642-643.
Sukor, Norlela ; Azml, K. Nor ; Khalid, B. A K. / Pituitary thyroid resistance syndrome. In: Medical Journal of Malaysia. 2005 ; Vol. 60, No. 5. pp. 642-643.
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