Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats

Khin Pa Pa Hlaing @ Farida Hussan, Nur Nazilah Bt Mat Zin, Mohd Ramdzi Bin Zullkefli, Yow Siew Choon, Noor Adibah Bt Abdullah, Seong Lin Teoh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Piper sarmentosum has been shown to possess antihyperglycemic effect. The effect of water extract of PS leaves was determined on the diabetic complications in streptozotocin induced rats. Eighteen male Sprague Dawley rats (n=18) were randomly divided into three groups with six rats each, namely, control, diabetic untreated and PS treated diabetic groups. Diabetes was induced with intramuscular injection of STZ (50 mg/kg). Ten days following the induction, the diabetes was confirmed with fasting blood sugar level more than 8 mmol/L and PS extract was administered orally (0.125 g/kg) for 28 days. The left kidneys were collected to analyze. The body weight and kidney weight index showed significant differences between control and diabetic groups (p<0.05). However, the lesser extent of body weight gain was observed in diabetic group compared with the control groups. The fasting blood sugar level was reduced in PS treated group. The percent area occupied by the glomerulus over a renal corpuscle was found to be 74.5% in DPS, 72% in DNT and 75% in C group; however it was statistically insignificant. Histological study revealed marked inflammatory cells infiltration and glomeruli contraction with widened urinary spaces revealed in DNT group following 28 days of hyperglycemic state whereas the DPS group showed features of improvement. The water extract of PS leaves has the potential preventive effect on the diabetic nephropathy by reducing hyperglycemia.

Original languageEnglish
Pages (from-to)1605-1612
Number of pages8
JournalSains Malaysiana
Volume42
Issue number11
Publication statusPublished - Nov 2013

Fingerprint

2,6-dinitrotoluene
Piper
Diabetes Complications
Streptozocin
Sprague Dawley Rats
Kidney
Blood Glucose
Water
Fasting
Body Weight
Control Groups
Intramuscular Injections
Diabetic Nephropathies
Hypoglycemic Agents
Hyperglycemia
Weight Gain
Weights and Measures

Keywords

  • Diabetic nephropathies
  • Piper sarmentosum
  • Streptozotocin

ASJC Scopus subject areas

  • General

Cite this

Pa Pa Hlaing @ Farida Hussan, K., Bt Mat Zin, N. N., Zullkefli, M. R. B., Choon, Y. S., Bt Abdullah, N. A., & Teoh, S. L. (2013). Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats. Sains Malaysiana, 42(11), 1605-1612.

Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats. / Pa Pa Hlaing @ Farida Hussan, Khin; Bt Mat Zin, Nur Nazilah; Zullkefli, Mohd Ramdzi Bin; Choon, Yow Siew; Bt Abdullah, Noor Adibah; Teoh, Seong Lin.

In: Sains Malaysiana, Vol. 42, No. 11, 11.2013, p. 1605-1612.

Research output: Contribution to journalArticle

Pa Pa Hlaing @ Farida Hussan, K, Bt Mat Zin, NN, Zullkefli, MRB, Choon, YS, Bt Abdullah, NA & Teoh, SL 2013, 'Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats', Sains Malaysiana, vol. 42, no. 11, pp. 1605-1612.
Pa Pa Hlaing @ Farida Hussan K, Bt Mat Zin NN, Zullkefli MRB, Choon YS, Bt Abdullah NA, Teoh SL. Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats. Sains Malaysiana. 2013 Nov;42(11):1605-1612.
Pa Pa Hlaing @ Farida Hussan, Khin ; Bt Mat Zin, Nur Nazilah ; Zullkefli, Mohd Ramdzi Bin ; Choon, Yow Siew ; Bt Abdullah, Noor Adibah ; Teoh, Seong Lin. / Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats. In: Sains Malaysiana. 2013 ; Vol. 42, No. 11. pp. 1605-1612.
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