Piper sarmentosum roxb protects lungs against oxidative stress induced by carbon tetrachloride in rats

Nur Azlina Mohd Fahami, Kamisah Yusof, Reeny F A Rahman, Faizah Othman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This study was designed to investigate the effects of Piper sarmentosum supplementation on carbon tetrachloride (CCl4) induced oxidative stress in lung. Thirty-two male Wistar rats were divided into two groups; a control and a treatment group which was given 125 mg/kg body weight P. sarmentosum orally for 28 days, after which each group was further subdivided into two groups. A group was exposed to CCl4 (1 ml/kg body weight, orally) while another group was given corn oil. After 24 h, blood and lung were taken. CCl4 increased lung lipid peroxidation (TBARS) and glutathione peroxidase significantly. P. sarmentosum supplementation was able to reduce these increases. However, both CCl4 and P. sarmentosum extract did not affect lung superoxide dismutase activity. In conclusion, P. sarmentosum is capable in reducing the oxidative stress in lungs by decreasing lipid peroxidation and maintaining the glutathione peroxidase activity towards the normal level.

Original languageEnglish
Pages (from-to)6128-6135
Number of pages8
JournalJournal of Medicinal Plant Research
Volume5
Issue number26
DOIs
Publication statusPublished - Nov 2011

Fingerprint

Piper
carbon tetrachloride
Carbon Tetrachloride
Oxidative Stress
oxidative stress
lungs
Lung
rats
Glutathione Peroxidase
glutathione peroxidase
Lipid Peroxidation
lipid peroxidation
Body Weight
Corn Oil
body weight
corn oil
thiobarbituric acid-reactive substances
Superoxide Dismutase
Wistar Rats
superoxide dismutase

Keywords

  • Antioxidant
  • Carbon tetrachloride
  • Oxidative stress
  • Piper sarmentosum

ASJC Scopus subject areas

  • Pharmacology
  • Complementary and alternative medicine
  • Drug Discovery
  • Plant Science
  • Pharmaceutical Science

Cite this

Piper sarmentosum roxb protects lungs against oxidative stress induced by carbon tetrachloride in rats. / Mohd Fahami, Nur Azlina; Yusof, Kamisah; Rahman, Reeny F A; Othman, Faizah.

In: Journal of Medicinal Plant Research, Vol. 5, No. 26, 11.2011, p. 6128-6135.

Research output: Contribution to journalArticle

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