Phytonutrients

Experimental effects on gastric lesions in rats exposed to acute repetitive restraint stress

Nur Azlina Mohd Fahami, Nafeeza Mohd Ismail, Khalid Bin Abdul Kadir

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose - This study seeks to investigate the effect of palm-based phytonutrient complex (PPC) on stress-induced gastric lesions and accompanying changes in the gastric acidity and gastrin level. Design/methodology/approach - A total of 40 rats were divided between a control group that was given a vitamin E deficient diet and a treatment group that was given a vitamin deficient diet with oral supplementation of PPC at 60 mg/kg body weight for 28 days. At the end of the treatment period half of the number of rats were subjected to restraint-stress for two hours for four consecutive days. Following stress exposure, blood was taken for measurement of gastrin level, after which all the rats were disposed of. The gastric acid was collected for measurement of acid concentration, while the stomachs were opened along the greater curvature and examined for lesions. Findings - Rats exposed to stress developed hemorrhagic gastric lesions. PPC supplemented rats had fewer gastric lesions compared with their respective control group. Stress without supplementation with PPC also caused a reduction in the gastric acid concentration and the serum gastrin levels. Compared with their corresponding controls, the pre- and post-values of gastric acid and serum gastrin concentration in rats with PPC supplementation remained comparable. Originality/value - Stress is an identified risk factor for the development of gastric lesions. The current study showed that PPC was able to reduce the development of gastric lesions induced by stress and blocks the stress-induced changes in the gastric acid concentration and gastrin level. It is possible that part of the protective effect of PPC in stress is through maintenance of the normal gastrin level, which results in the maintenance of gastrin trophic action in the gastric mucosa.

Original languageEnglish
Pages (from-to)403-409
Number of pages7
JournalNutrition and Food Science
Volume35
Issue number6
DOIs
Publication statusPublished - 2005

Fingerprint

gastrins
Gastrins
Phytochemicals
lesions (animal)
Stomach
stomach
gastric acid
Gastric Acid
rats
blood serum
Maintenance
Diet
Control Groups
gastric mucosa
Gastric Mucosa
Serum
Vitamin E
Vitamins
diet
protective effect

Keywords

  • Body systems and organs
  • Diet
  • Stress
  • Vitamins

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Phytonutrients : Experimental effects on gastric lesions in rats exposed to acute repetitive restraint stress. / Mohd Fahami, Nur Azlina; Ismail, Nafeeza Mohd; Kadir, Khalid Bin Abdul.

In: Nutrition and Food Science, Vol. 35, No. 6, 2005, p. 403-409.

Research output: Contribution to journalArticle

@article{b36e857206ef42efa74eb5faeb7e1d64,
title = "Phytonutrients: Experimental effects on gastric lesions in rats exposed to acute repetitive restraint stress",
abstract = "Purpose - This study seeks to investigate the effect of palm-based phytonutrient complex (PPC) on stress-induced gastric lesions and accompanying changes in the gastric acidity and gastrin level. Design/methodology/approach - A total of 40 rats were divided between a control group that was given a vitamin E deficient diet and a treatment group that was given a vitamin deficient diet with oral supplementation of PPC at 60 mg/kg body weight for 28 days. At the end of the treatment period half of the number of rats were subjected to restraint-stress for two hours for four consecutive days. Following stress exposure, blood was taken for measurement of gastrin level, after which all the rats were disposed of. The gastric acid was collected for measurement of acid concentration, while the stomachs were opened along the greater curvature and examined for lesions. Findings - Rats exposed to stress developed hemorrhagic gastric lesions. PPC supplemented rats had fewer gastric lesions compared with their respective control group. Stress without supplementation with PPC also caused a reduction in the gastric acid concentration and the serum gastrin levels. Compared with their corresponding controls, the pre- and post-values of gastric acid and serum gastrin concentration in rats with PPC supplementation remained comparable. Originality/value - Stress is an identified risk factor for the development of gastric lesions. The current study showed that PPC was able to reduce the development of gastric lesions induced by stress and blocks the stress-induced changes in the gastric acid concentration and gastrin level. It is possible that part of the protective effect of PPC in stress is through maintenance of the normal gastrin level, which results in the maintenance of gastrin trophic action in the gastric mucosa.",
keywords = "Body systems and organs, Diet, Stress, Vitamins",
author = "{Mohd Fahami}, {Nur Azlina} and Ismail, {Nafeeza Mohd} and Kadir, {Khalid Bin Abdul}",
year = "2005",
doi = "10.1108/00346650510633800",
language = "English",
volume = "35",
pages = "403--409",
journal = "Nutrition and Food Science",
issn = "0034-6659",
publisher = "Emerald Group Publishing Ltd.",
number = "6",

}

TY - JOUR

T1 - Phytonutrients

T2 - Experimental effects on gastric lesions in rats exposed to acute repetitive restraint stress

AU - Mohd Fahami, Nur Azlina

AU - Ismail, Nafeeza Mohd

AU - Kadir, Khalid Bin Abdul

PY - 2005

Y1 - 2005

N2 - Purpose - This study seeks to investigate the effect of palm-based phytonutrient complex (PPC) on stress-induced gastric lesions and accompanying changes in the gastric acidity and gastrin level. Design/methodology/approach - A total of 40 rats were divided between a control group that was given a vitamin E deficient diet and a treatment group that was given a vitamin deficient diet with oral supplementation of PPC at 60 mg/kg body weight for 28 days. At the end of the treatment period half of the number of rats were subjected to restraint-stress for two hours for four consecutive days. Following stress exposure, blood was taken for measurement of gastrin level, after which all the rats were disposed of. The gastric acid was collected for measurement of acid concentration, while the stomachs were opened along the greater curvature and examined for lesions. Findings - Rats exposed to stress developed hemorrhagic gastric lesions. PPC supplemented rats had fewer gastric lesions compared with their respective control group. Stress without supplementation with PPC also caused a reduction in the gastric acid concentration and the serum gastrin levels. Compared with their corresponding controls, the pre- and post-values of gastric acid and serum gastrin concentration in rats with PPC supplementation remained comparable. Originality/value - Stress is an identified risk factor for the development of gastric lesions. The current study showed that PPC was able to reduce the development of gastric lesions induced by stress and blocks the stress-induced changes in the gastric acid concentration and gastrin level. It is possible that part of the protective effect of PPC in stress is through maintenance of the normal gastrin level, which results in the maintenance of gastrin trophic action in the gastric mucosa.

AB - Purpose - This study seeks to investigate the effect of palm-based phytonutrient complex (PPC) on stress-induced gastric lesions and accompanying changes in the gastric acidity and gastrin level. Design/methodology/approach - A total of 40 rats were divided between a control group that was given a vitamin E deficient diet and a treatment group that was given a vitamin deficient diet with oral supplementation of PPC at 60 mg/kg body weight for 28 days. At the end of the treatment period half of the number of rats were subjected to restraint-stress for two hours for four consecutive days. Following stress exposure, blood was taken for measurement of gastrin level, after which all the rats were disposed of. The gastric acid was collected for measurement of acid concentration, while the stomachs were opened along the greater curvature and examined for lesions. Findings - Rats exposed to stress developed hemorrhagic gastric lesions. PPC supplemented rats had fewer gastric lesions compared with their respective control group. Stress without supplementation with PPC also caused a reduction in the gastric acid concentration and the serum gastrin levels. Compared with their corresponding controls, the pre- and post-values of gastric acid and serum gastrin concentration in rats with PPC supplementation remained comparable. Originality/value - Stress is an identified risk factor for the development of gastric lesions. The current study showed that PPC was able to reduce the development of gastric lesions induced by stress and blocks the stress-induced changes in the gastric acid concentration and gastrin level. It is possible that part of the protective effect of PPC in stress is through maintenance of the normal gastrin level, which results in the maintenance of gastrin trophic action in the gastric mucosa.

KW - Body systems and organs

KW - Diet

KW - Stress

KW - Vitamins

UR - http://www.scopus.com/inward/record.url?scp=29544441927&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29544441927&partnerID=8YFLogxK

U2 - 10.1108/00346650510633800

DO - 10.1108/00346650510633800

M3 - Article

VL - 35

SP - 403

EP - 409

JO - Nutrition and Food Science

JF - Nutrition and Food Science

SN - 0034-6659

IS - 6

ER -