Phytochemical properties and cytotoxicity evaluation of the aqueous extracts from Rafflesia cantleyi

Sumaia Mohamed Mohamed Bakoush, Wan Yaacob Wan Ahmad, Jumaat Adam, Nazlina Ibrahim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the present study, phytochemical properties and cytotoxic evaluation of aqueous extract of Rafflesia cantleyi bud parts were done. Three bud parts including disk, bract and perigone tube were extracted in water to produce crude aqueous extract. Cytotoxic activity of R. cantleyi bud parts was assessed by conducting 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against normal cells Vero, 3T3 cell lines and mice peripheral blood mononuclear cells PBMC. Phytochemical analyses revealed the presence of tannins, flavonoids, steroids and alkaloids. The CC50 value against Vero, 3T3 and PBMC cells were equal or more than 125 μg/ml indicating the non-cytotoxic effect of the bud parts extracts. The finding revealed that crude extracts of all the tested bud parts contained potential bioactive compounds which can be used for various biological activities and have no cytotoxicity to selected normal cells.

Original languageEnglish
Title of host publication2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium
PublisherAmerican Institute of Physics Inc.
Volume1678
ISBN (Electronic)9780735413252
DOIs
Publication statusPublished - 25 Sep 2015
Event2015 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2015 - Selangor, Malaysia
Duration: 15 Apr 201516 Apr 2015

Other

Other2015 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2015
CountryMalaysia
CitySelangor
Period15/4/1516/4/15

Fingerprint

activity (biology)
evaluation
cells
blood cells
steroids
alkaloids
cultured cells
mice
bromides
tubes
conduction
water

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Bakoush, S. M. M., Wan Ahmad, W. Y., Adam, J., & Ibrahim, N. (2015). Phytochemical properties and cytotoxicity evaluation of the aqueous extracts from Rafflesia cantleyi. In 2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium (Vol. 1678). [030015] American Institute of Physics Inc.. https://doi.org/10.1063/1.4931236

Phytochemical properties and cytotoxicity evaluation of the aqueous extracts from Rafflesia cantleyi. / Bakoush, Sumaia Mohamed Mohamed; Wan Ahmad, Wan Yaacob; Adam, Jumaat; Ibrahim, Nazlina.

2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium. Vol. 1678 American Institute of Physics Inc., 2015. 030015.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bakoush, SMM, Wan Ahmad, WY, Adam, J & Ibrahim, N 2015, Phytochemical properties and cytotoxicity evaluation of the aqueous extracts from Rafflesia cantleyi. in 2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium. vol. 1678, 030015, American Institute of Physics Inc., 2015 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2015, Selangor, Malaysia, 15/4/15. https://doi.org/10.1063/1.4931236
Bakoush SMM, Wan Ahmad WY, Adam J, Ibrahim N. Phytochemical properties and cytotoxicity evaluation of the aqueous extracts from Rafflesia cantleyi. In 2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium. Vol. 1678. American Institute of Physics Inc. 2015. 030015 https://doi.org/10.1063/1.4931236
Bakoush, Sumaia Mohamed Mohamed ; Wan Ahmad, Wan Yaacob ; Adam, Jumaat ; Ibrahim, Nazlina. / Phytochemical properties and cytotoxicity evaluation of the aqueous extracts from Rafflesia cantleyi. 2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium. Vol. 1678 American Institute of Physics Inc., 2015.
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