Physicochemical and structural characterization of surface modified electrospun PMMA nanofibre

Rabiatul Adawiyah Razali, Lokanathan Yogeswaran, Shiplu Roy Chowdhury, Aminuddin Saim, Ruszymah Idrus

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Although electrospun poly(methyl methacrylate) (PMMA) may mimic structural features of extracellular matrix, its highly hydrophobic nature causes reduced cell attachment. This study analysed the physicochemical and structural changes of the surface modified PMMA nanofiber. The electrospun PMMA nanofibers (PM) were surface-treated as follows: PM alone, collagen coated-PM (PM-C), UV-irradiated PM (PM-UV), collagen coated UV-irradiated PM (PM-C-UV) and collagen coated-PM crosslinked with genipin (PM-C-GEN). They were subjected to scanning electron microscopy, Fourier transform infrared (FTIR), cell attachment analysis, X-ray photoelectron spectroscopy (XPS), atomic force microscopy and X-ray powder diffraction (XRD). The surface roughness was lower in PM-C-UV group compared to others. Based on FTIR results, all expected functional group were present in all groups. XPS result showed that there are changes in the mass concentration of UV-treated surfaces and in the collagen coated surfaces. All PM groups showed amorphous nature through XRD. UV irradiation and collagen coating were shown to increase PM's functional groups and modify its surface, which contributed to the increased attachment of cells onto the inert PM scaffold. As conclusion, collagen coated UV irradiated PMMA provided a better surface for cell to attach hence are suitable to be used further as scaffold for in vitro model.

Original languageEnglish
Pages (from-to)1787-1794
Number of pages8
JournalSains Malaysiana
Volume47
Issue number8
DOIs
Publication statusPublished - 1 Aug 2018

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Nanofibers
Polymethyl Methacrylate
Collagen
Powder Diffraction
Photoelectron Spectroscopy
Fourier Analysis
X-Ray Diffraction
Atomic Force Microscopy

Keywords

  • Electrospun nanofiber
  • PMMA
  • Scaffold
  • Surface modification
  • UV irradiation

ASJC Scopus subject areas

  • General

Cite this

Physicochemical and structural characterization of surface modified electrospun PMMA nanofibre. / Razali, Rabiatul Adawiyah; Yogeswaran, Lokanathan; Chowdhury, Shiplu Roy; Saim, Aminuddin; Idrus, Ruszymah.

In: Sains Malaysiana, Vol. 47, No. 8, 01.08.2018, p. 1787-1794.

Research output: Contribution to journalArticle

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