Sifat Fizikal dan Kajian in Vitro Tablet Matriks Pelepasan Tertahan Ketoprofen

Translated title of the contribution: Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets

Ibrahim Ijang, Mohd Cairul Iqbal Mohd Amin, Bukhori Abu Bakar

Research output: Contribution to journalArticle

Abstract

The use of sustained release tablet formulation for non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin has the capability to protect the stomach lining from the adverse effect of gastric juice from the body. This study was carried out to evaluate the efficiency of sustained release matrix tablet formulation using ketoprofen as a model drug with different polymers concentration. The tablets were prepared by the wet granulation method using hydrophilic polymer (hydroxypropyl methylcellulose), hydrophobic pH dependent polymer (Eudragit L100-55) and independent polymer (Eudragit RD100) as matrix forming retarding materials at 10,20 and 30%w/w. All formulations were compressed using 10 mm concave faced punches. The compressed tablets were evaluated for uniformity of weight, friability, hardness, thickness, percent drug content and in vitro dissolution test with regard to BP 2007. The results showed that the drug release rate was found to be governed by the type and concentration of polymer in the matrix system. Generally, increasing the polymeric concentration in the matrix tablets will decrease the rate of drug release. When the polymers were compared at similar concentration using t 50%, the difference in drug release was found to be statistically significant (p<0.05). Based on the in vitro drug dissolution studies, the hydrophobic pH dependent polymer (Eudragit L100-55) showed a better zero drug release profile compared to other polymers.

Original languageUndefined/Unknown
Pages (from-to)737-745
Number of pages9
JournalSains Malaysiana
Volume39
Issue number5
Publication statusPublished - Oct 2010

Fingerprint

Ketoprofen
Tablets
Polymers
Pharmaceutical Preparations
Gastric Juice
In Vitro Techniques
Hardness
Aspirin
Stomach
Anti-Inflammatory Agents
Drug Liberation
Weights and Measures

Keywords

  • In vitro dissolution
  • Ketoprofen
  • Matrix tablets
  • Sustained release

ASJC Scopus subject areas

  • General

Cite this

Sifat Fizikal dan Kajian in Vitro Tablet Matriks Pelepasan Tertahan Ketoprofen. / Ijang, Ibrahim; Mohd Amin, Mohd Cairul Iqbal; Abu Bakar, Bukhori.

In: Sains Malaysiana, Vol. 39, No. 5, 10.2010, p. 737-745.

Research output: Contribution to journalArticle

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