Photopic and scotopic multifocal pupillographic responses in age-related macular degeneration

Yanti Rosli, S. M. Bedford, A. C. James, T. Maddess

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We compared photopic and scotopic multifocal pupillographic stimuli in age-related macular degeneration (AMD). Both eyes of 18 normal and 14 AMD subjects were tested with four stimulus variants presented at photopic and 126 times lower luminances. The multifocal stimuli presented 24 test regions/eye to the central 60° The stimulus variants had two different check sizes, and when presented either flickered (15. Hz) for 266. ms, or were steady for 133. ms. Mean differences from normal of 5 to 7. dB were observed in the central visual field for both photopic and scotopic stimuli (all p< 0.00002). The best areas under receiver operating characteristic plots for exudative AMD in the photopic and scotopic conditions were 92.9. ± 8.0 and 90.3 ± 5.7% respectively, and in less severely affected eyes 83.8 ± 9.7% and 76.9 ± 8.2%. Damage recorded at photopic levels was possibly more diffusely distributed across the visual field. Sensitivity and specificity was similar at photopic and scotopic levels.

Original languageEnglish
Pages (from-to)42-48
Number of pages7
JournalVision Research
Volume69
DOIs
Publication statusPublished - 15 Sep 2012

Fingerprint

Macular Degeneration
Visual Fields
ROC Curve
Sensitivity and Specificity

Keywords

  • Age-related macular degeneration
  • Multifocal pupillography
  • Pedestal flicker
  • Photopic
  • Scotopic

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Photopic and scotopic multifocal pupillographic responses in age-related macular degeneration. / Rosli, Yanti; Bedford, S. M.; James, A. C.; Maddess, T.

In: Vision Research, Vol. 69, 15.09.2012, p. 42-48.

Research output: Contribution to journalArticle

Rosli, Yanti ; Bedford, S. M. ; James, A. C. ; Maddess, T. / Photopic and scotopic multifocal pupillographic responses in age-related macular degeneration. In: Vision Research. 2012 ; Vol. 69. pp. 42-48.
@article{204a395e79e6488aaf1e81675c8f7c98,
title = "Photopic and scotopic multifocal pupillographic responses in age-related macular degeneration",
abstract = "We compared photopic and scotopic multifocal pupillographic stimuli in age-related macular degeneration (AMD). Both eyes of 18 normal and 14 AMD subjects were tested with four stimulus variants presented at photopic and 126 times lower luminances. The multifocal stimuli presented 24 test regions/eye to the central 60° The stimulus variants had two different check sizes, and when presented either flickered (15. Hz) for 266. ms, or were steady for 133. ms. Mean differences from normal of 5 to 7. dB were observed in the central visual field for both photopic and scotopic stimuli (all p< 0.00002). The best areas under receiver operating characteristic plots for exudative AMD in the photopic and scotopic conditions were 92.9. ± 8.0 and 90.3 ± 5.7{\%} respectively, and in less severely affected eyes 83.8 ± 9.7{\%} and 76.9 ± 8.2{\%}. Damage recorded at photopic levels was possibly more diffusely distributed across the visual field. Sensitivity and specificity was similar at photopic and scotopic levels.",
keywords = "Age-related macular degeneration, Multifocal pupillography, Pedestal flicker, Photopic, Scotopic",
author = "Yanti Rosli and Bedford, {S. M.} and James, {A. C.} and T. Maddess",
year = "2012",
month = "9",
day = "15",
doi = "10.1016/j.visres.2012.07.019",
language = "English",
volume = "69",
pages = "42--48",
journal = "Vision Research",
issn = "0042-6989",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Photopic and scotopic multifocal pupillographic responses in age-related macular degeneration

AU - Rosli, Yanti

AU - Bedford, S. M.

AU - James, A. C.

AU - Maddess, T.

PY - 2012/9/15

Y1 - 2012/9/15

N2 - We compared photopic and scotopic multifocal pupillographic stimuli in age-related macular degeneration (AMD). Both eyes of 18 normal and 14 AMD subjects were tested with four stimulus variants presented at photopic and 126 times lower luminances. The multifocal stimuli presented 24 test regions/eye to the central 60° The stimulus variants had two different check sizes, and when presented either flickered (15. Hz) for 266. ms, or were steady for 133. ms. Mean differences from normal of 5 to 7. dB were observed in the central visual field for both photopic and scotopic stimuli (all p< 0.00002). The best areas under receiver operating characteristic plots for exudative AMD in the photopic and scotopic conditions were 92.9. ± 8.0 and 90.3 ± 5.7% respectively, and in less severely affected eyes 83.8 ± 9.7% and 76.9 ± 8.2%. Damage recorded at photopic levels was possibly more diffusely distributed across the visual field. Sensitivity and specificity was similar at photopic and scotopic levels.

AB - We compared photopic and scotopic multifocal pupillographic stimuli in age-related macular degeneration (AMD). Both eyes of 18 normal and 14 AMD subjects were tested with four stimulus variants presented at photopic and 126 times lower luminances. The multifocal stimuli presented 24 test regions/eye to the central 60° The stimulus variants had two different check sizes, and when presented either flickered (15. Hz) for 266. ms, or were steady for 133. ms. Mean differences from normal of 5 to 7. dB were observed in the central visual field for both photopic and scotopic stimuli (all p< 0.00002). The best areas under receiver operating characteristic plots for exudative AMD in the photopic and scotopic conditions were 92.9. ± 8.0 and 90.3 ± 5.7% respectively, and in less severely affected eyes 83.8 ± 9.7% and 76.9 ± 8.2%. Damage recorded at photopic levels was possibly more diffusely distributed across the visual field. Sensitivity and specificity was similar at photopic and scotopic levels.

KW - Age-related macular degeneration

KW - Multifocal pupillography

KW - Pedestal flicker

KW - Photopic

KW - Scotopic

UR - http://www.scopus.com/inward/record.url?scp=84865316171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865316171&partnerID=8YFLogxK

U2 - 10.1016/j.visres.2012.07.019

DO - 10.1016/j.visres.2012.07.019

M3 - Article

C2 - 22898702

AN - SCOPUS:84865316171

VL - 69

SP - 42

EP - 48

JO - Vision Research

JF - Vision Research

SN - 0042-6989

ER -