Photobiostimulation effect on diabetic wound at different power density of near infrared laser

Piksuan Lau, Noriah Bidin, Ganesan Krishnan, Sana Mohammed AnaybBaleg, Mohamad Bin Md Sum, Hazri Bakhtiar, Zaleha Nassir, Asmah Hamid

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The photobiostimulation effects of near infrared 808 nm diode laser irradiance on diabetic wound were investigated. 120 rats were induced with diabetes by streptozotocin injection. Full thickness punch wounds of 6 mm diameter were created on the dorsal part of the rats. All rats were randomly distributed into four groups; one group served as control group, whereas three groups were stimulated daily with unchanged energy density dose of 5 J/cm2 with different power density, which were 0.1 W/cm2, 0.2 W/cm2 and 0.3 W/cm2 with different exposure duration of 50 s, 25 s and 17 s, respectively. Ten rats from each group were sacrificed on day 3, 6 and 9, respectively. Skin tissues were removed for histological purpose. The contraction of wound was found optimized after exposure with 0.1 W/cm2. Based on the histological evidence, laser therapy has shown able to promote wound repair through enhanced epithelialization and collagen fiber synthesis. Generally, irradiated groups were advanced in terms of healing than non-irradiated group.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalJournal of Photochemistry and Photobiology B: Biology
Volume151
DOIs
Publication statusPublished - 26 Oct 2015

Fingerprint

infrared lasers
radiant flux density
Lasers
Wounds and Injuries
rats
Semiconductor Lasers
Experimental Diabetes Mellitus
Laser Therapy
Collagen
punches
healing
Control Groups
Skin
Injections
collagens
irradiance
contraction
therapy
flux density
semiconductor lasers

Keywords

  • Diabetic
  • Diode laser
  • Histological
  • Photobiostimulation
  • Therapy
  • Wound healing

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

Photobiostimulation effect on diabetic wound at different power density of near infrared laser. / Lau, Piksuan; Bidin, Noriah; Krishnan, Ganesan; AnaybBaleg, Sana Mohammed; Sum, Mohamad Bin Md; Bakhtiar, Hazri; Nassir, Zaleha; Hamid, Asmah.

In: Journal of Photochemistry and Photobiology B: Biology, Vol. 151, 26.10.2015, p. 201-207.

Research output: Contribution to journalArticle

Lau, Piksuan ; Bidin, Noriah ; Krishnan, Ganesan ; AnaybBaleg, Sana Mohammed ; Sum, Mohamad Bin Md ; Bakhtiar, Hazri ; Nassir, Zaleha ; Hamid, Asmah. / Photobiostimulation effect on diabetic wound at different power density of near infrared laser. In: Journal of Photochemistry and Photobiology B: Biology. 2015 ; Vol. 151. pp. 201-207.
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