Phenolic constituents from the wood of Morus australis with cytotoxic activity

Ferlinahayati, Yana M. Syah, Lia D. Juliawaty, Sjamsul A. Achmad, Euis H. Hakim, Hiromitsu Takayama, Ikram M. Said, Jalifah Latip

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A new methylated flavonol, 5,7,2′,4′-tetrahydroxy-3- methoxyflavone (1), had been isolated from the methanol extract of the wood of Morus australis, along with nine known compounds, kuwanon C (2), morusin (3), morachalcone A (4), oxyresveratrol (5), 4′-(2-methyl-2-buten-4-yl) oxyresveratrol (6), moracins M (7) and C (8), alboctalol (9), and macrourin B (10). The structures of these compounds were determined based on spectral evidence, including UV, IR, NMR, and mass spectra. Cytotoxic properties of compounds 1-10 were evaluated against murine leukemia P-388 cells. The prenylated stilbene 6 and 2-arylbenzofuran 8, and morusin (3) were found to have strong cytotoxic effects with IC50 values of 6.9, 8.7, and 10.1 μM, respectively.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume63
Issue number1-2
Publication statusPublished - Jan 2008

Fingerprint

Morus australis
wood extractives
Morus
stilbenes
flavonols
leukemia
inhibitory concentration 50
cytotoxicity
Wood
methanol
Stilbenes
mice
Inhibitory Concentration 50
Methanol
Leukemia
Nuclear magnetic resonance
cells
morusin
puag-haad

Keywords

  • 5,7,2′,4′- Tetrahydroxy-3-methoxyflavone
  • Morus australis
  • Murine leukemia P-388 cells

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Ferlinahayati, Syah, Y. M., Juliawaty, L. D., Achmad, S. A., Hakim, E. H., Takayama, H., ... Latip, J. (2008). Phenolic constituents from the wood of Morus australis with cytotoxic activity. Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 63(1-2), 35-39.

Phenolic constituents from the wood of Morus australis with cytotoxic activity. / Ferlinahayati; Syah, Yana M.; Juliawaty, Lia D.; Achmad, Sjamsul A.; Hakim, Euis H.; Takayama, Hiromitsu; Said, Ikram M.; Latip, Jalifah.

In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences, Vol. 63, No. 1-2, 01.2008, p. 35-39.

Research output: Contribution to journalArticle

Ferlinahayati, Syah, YM, Juliawaty, LD, Achmad, SA, Hakim, EH, Takayama, H, Said, IM & Latip, J 2008, 'Phenolic constituents from the wood of Morus australis with cytotoxic activity', Zeitschrift fur Naturforschung - Section C Journal of Biosciences, vol. 63, no. 1-2, pp. 35-39.
Ferlinahayati, Syah YM, Juliawaty LD, Achmad SA, Hakim EH, Takayama H et al. Phenolic constituents from the wood of Morus australis with cytotoxic activity. Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 2008 Jan;63(1-2):35-39.
Ferlinahayati ; Syah, Yana M. ; Juliawaty, Lia D. ; Achmad, Sjamsul A. ; Hakim, Euis H. ; Takayama, Hiromitsu ; Said, Ikram M. ; Latip, Jalifah. / Phenolic constituents from the wood of Morus australis with cytotoxic activity. In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 2008 ; Vol. 63, No. 1-2. pp. 35-39.
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