Pharmacogenomics screening of HLA-B*1502 in epilepsy patients

How we do it in the UKM medical centre, Malaysia

Sue Mian Then, Zam Zureena Mohd Rani, Raymond Azman Ali, A. Rahman A. Jamal

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Previous studies have shown that carbamazepine-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) patients is associated with the HLA-B*1502 allele. Screening for HLA-B*1502 before using carbamazepine can prevent SJS/TEN particularly in populations with high frequency of the allele. The objective of this paper was to describe how the UKM Medical Centre, Malaysia was able to set up a cost effective screening of HLA-B*1502 for patients taking carbamazepine. The cost of in-house HLA-B/1502 screening was less than those commercially available, and was sensitive and specific.

Original languageEnglish
Pages (from-to)27-29
Number of pages3
JournalNeurology Asia
Volume18
Issue numberSUPPL. 1
Publication statusPublished - 2013

Fingerprint

HLA-B Antigens
Malaysia
Epilepsy
Carbamazepine
Stevens-Johnson Syndrome
Costs and Cost Analysis
Gene Frequency
Alleles
Pharmacogenomic Testing
Population

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Pharmacogenomics screening of HLA-B*1502 in epilepsy patients : How we do it in the UKM medical centre, Malaysia. / Then, Sue Mian; Rani, Zam Zureena Mohd; Ali, Raymond Azman; A. Jamal, A. Rahman.

In: Neurology Asia, Vol. 18, No. SUPPL. 1, 2013, p. 27-29.

Research output: Contribution to journalArticle

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