Pesticide Exposure and Cardiovascular Hemodynamic Parameters among Male Workers Involved in Mosquito Control in East Coast of Malaysia

Niza Samsuddin, Krishna Gopal Rampal, Noor Hassim Ismail, Nor Zamzila Abdullah, Hashima E. Nasreen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BACKGROUND Research findings have linked exposure to pesticides to an increased risk of cardiovascular (CVS) diseases. Therefore, this study aimed to assess the impact of chronic mix-pesticides exposure on CVS hemodynamic parameters. METHODS A total of 198 male Malay pesticide-exposed and 195 male Malay nonexposed workers were examined. Data were collected through exposure-matrix assessment, questionnaire, blood analyses, and CVS assessment. Explanatory variables comprised of lipid profiles, paraoxonase 1 (PON1), and oxidized low-density lipoprotein (ox-LDL). Outcome measures comprised of brachial and aortic diastolic blood pressure (DBP) and systolic BP (SBP), heart rate, and pulse wave velocity (PWV). Linear regressions identified the B coefficient showing how many units of CVS parameters are associated with each unit of covariates. RESULTS Diazoxonase was significantly lower and ox-LDL was higher among pesticide-exposed workers than the comparison group. The final multivariate linear regression model revealed that age, body mass index (BMI), smoking, and pesticide exposure were independent predictors of brachial and aortic DBP and SBP. Pesticide exposure was also associated with heart rate, but not with PWV. Lipid profiles, PON1 enzymes, and ox-LDL showed no association with any of the CVS parameters. CONCLUSIONS Chronic mix-pesticide exposure among workers involved in mosquito control has possible association with depression of diazoxonase and the increase in ox-LDL, brachial and aortic DBP and SBP, and heart rate. This study raises concerns that those using pesticides may be exposed to hitherto unrecognized CVS risks among others. If this is confirmed by further studies, greater efforts will be needed to protect these workers.

Original languageEnglish
Pages (from-to)226-233
Number of pages8
JournalAmerican Journal of Hypertension
Volume29
Issue number2
DOIs
Publication statusPublished - 1 Feb 2016

Fingerprint

Mosquito Control
Malaysia
Pesticides
Hemodynamics
Aryldialkylphosphatase
Linear Models
Arterial Pressure
Pulse Wave Analysis
Arm
Heart Rate
Blood Pressure
Lipids
Body Mass Index
Cardiovascular Diseases
Smoking
Outcome Assessment (Health Care)
oxidized low density lipoprotein

Keywords

  • diastolic blood pressure
  • hypertension
  • oxidized low-density lipoprotein
  • paraoxonase 1
  • pesticides
  • systolic blood pressure

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Pesticide Exposure and Cardiovascular Hemodynamic Parameters among Male Workers Involved in Mosquito Control in East Coast of Malaysia. / Samsuddin, Niza; Rampal, Krishna Gopal; Ismail, Noor Hassim; Abdullah, Nor Zamzila; Nasreen, Hashima E.

In: American Journal of Hypertension, Vol. 29, No. 2, 01.02.2016, p. 226-233.

Research output: Contribution to journalArticle

Samsuddin, Niza ; Rampal, Krishna Gopal ; Ismail, Noor Hassim ; Abdullah, Nor Zamzila ; Nasreen, Hashima E. / Pesticide Exposure and Cardiovascular Hemodynamic Parameters among Male Workers Involved in Mosquito Control in East Coast of Malaysia. In: American Journal of Hypertension. 2016 ; Vol. 29, No. 2. pp. 226-233.
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N2 - BACKGROUND Research findings have linked exposure to pesticides to an increased risk of cardiovascular (CVS) diseases. Therefore, this study aimed to assess the impact of chronic mix-pesticides exposure on CVS hemodynamic parameters. METHODS A total of 198 male Malay pesticide-exposed and 195 male Malay nonexposed workers were examined. Data were collected through exposure-matrix assessment, questionnaire, blood analyses, and CVS assessment. Explanatory variables comprised of lipid profiles, paraoxonase 1 (PON1), and oxidized low-density lipoprotein (ox-LDL). Outcome measures comprised of brachial and aortic diastolic blood pressure (DBP) and systolic BP (SBP), heart rate, and pulse wave velocity (PWV). Linear regressions identified the B coefficient showing how many units of CVS parameters are associated with each unit of covariates. RESULTS Diazoxonase was significantly lower and ox-LDL was higher among pesticide-exposed workers than the comparison group. The final multivariate linear regression model revealed that age, body mass index (BMI), smoking, and pesticide exposure were independent predictors of brachial and aortic DBP and SBP. Pesticide exposure was also associated with heart rate, but not with PWV. Lipid profiles, PON1 enzymes, and ox-LDL showed no association with any of the CVS parameters. CONCLUSIONS Chronic mix-pesticide exposure among workers involved in mosquito control has possible association with depression of diazoxonase and the increase in ox-LDL, brachial and aortic DBP and SBP, and heart rate. This study raises concerns that those using pesticides may be exposed to hitherto unrecognized CVS risks among others. If this is confirmed by further studies, greater efforts will be needed to protect these workers.

AB - BACKGROUND Research findings have linked exposure to pesticides to an increased risk of cardiovascular (CVS) diseases. Therefore, this study aimed to assess the impact of chronic mix-pesticides exposure on CVS hemodynamic parameters. METHODS A total of 198 male Malay pesticide-exposed and 195 male Malay nonexposed workers were examined. Data were collected through exposure-matrix assessment, questionnaire, blood analyses, and CVS assessment. Explanatory variables comprised of lipid profiles, paraoxonase 1 (PON1), and oxidized low-density lipoprotein (ox-LDL). Outcome measures comprised of brachial and aortic diastolic blood pressure (DBP) and systolic BP (SBP), heart rate, and pulse wave velocity (PWV). Linear regressions identified the B coefficient showing how many units of CVS parameters are associated with each unit of covariates. RESULTS Diazoxonase was significantly lower and ox-LDL was higher among pesticide-exposed workers than the comparison group. The final multivariate linear regression model revealed that age, body mass index (BMI), smoking, and pesticide exposure were independent predictors of brachial and aortic DBP and SBP. Pesticide exposure was also associated with heart rate, but not with PWV. Lipid profiles, PON1 enzymes, and ox-LDL showed no association with any of the CVS parameters. CONCLUSIONS Chronic mix-pesticide exposure among workers involved in mosquito control has possible association with depression of diazoxonase and the increase in ox-LDL, brachial and aortic DBP and SBP, and heart rate. This study raises concerns that those using pesticides may be exposed to hitherto unrecognized CVS risks among others. If this is confirmed by further studies, greater efforts will be needed to protect these workers.

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